Institute of Burn Research, State Key Laboratory of Trauma, Burn and Combined Injury, Southwest Hospital, Third Military Medical University, China
Scopus
Early Academic Pursuits 🎓
Mr. Yang Jiacai began his academic journey with a Master’s degree in Immunology from Shantou University (Guangdong, China) in 2013. His studies initially focused on skin immunology, where he delved into the physiological roles of immune cells such as γδ T cells, macrophages, and fibroblasts in wound healing. His work laid a strong foundation for his later research in skin wound healing mechanisms and the regulation of immune responses during tissue repair.
Professional Endeavors 💼
Currently, Mr. Yang is an experimentalist at the Institute of Burn Research, State Key Laboratory of Trauma, Burn and Combined Injury, Southwest Hospital, Third Military Medical University, Chongqing, China. His research is at the intersection of immunology and wound healing, particularly focusing on the roles of immune cells in skin repair and regeneration. His ongoing projects include a study on scarless wound healing in diabetic wounds and the exploration of DETC functions in burn injuries.
Contributions and Research Focus 🔬
Over the years, Mr. Yang has made significant contributions to the understanding of immune modulation in skin wound healing. His studies on the immune regulatory roles of fibroblast-secreted exosomes and Vγ4+ γδ T cells in macrophage polarization have opened new pathways for potential therapeutic approaches in wound healing. Moreover, his research on the antitumor activity of dendritic epidermal T cells (DETCs) has brought attention to their selective cytotoxicity and potential in cancer immunotherapy.
Impact and Influence 🌍
Mr. Yang’s work has garnered attention in the scientific community, as evidenced by his numerous publications in high-impact journals such as Journal of Investigative Dermatology and iScience. His research has not only contributed to advancing the field of skin wound healing but also provided key insights into immune cell dynamics that could influence cancer immunotherapy. His studies continue to impact both basic research and clinical practices related to burn injuries, wound healing, and tumor immunology.
Academic Cites 📚
Mr. Yang’s research has been widely cited, with several influential papers published in prestigious journals. For instance, his study on the selective cytotoxicity of skin-resident γδ T cells in tumor therapy has recently been published in Journal of Investigative Dermatology (November 2024). Other notable publications include his research on macrophage activation by fibroblast-exosomes in J Invest Dermatol (2025) and on MSCs’ role in angiogenesis in Front Immunol (2022). His work is increasingly recognized for its novel contributions to immunology and wound healing.
Technical Skills 🛠
Mr. Yang is highly skilled in various laboratory techniques related to immunology and skin biology. His expertise includes cellular immunology, flow cytometry, cell culture, wound healing assays, exosome isolation, and molecular biology techniques. Additionally, his proficiency in handling advanced in vitro and in vivo models allows him to investigate the dynamic interactions between immune cells, fibroblasts, and stem cells in skin repair and regeneration.
Teaching Experience 👨🏫
Mr. Yang has not listed formal teaching positions, his extensive knowledge and expertise in immunology and wound healing make him a valuable resource for mentorship and training in the lab. His guidance has likely shaped the careers of emerging researchers in the field, and his research collaborations reflect his commitment to knowledge-sharing within the scientific community.
Legacy and Future Contributions 🔮
Mr. Yang’s work has laid the groundwork for future breakthroughs in skin wound healing and cancer immunotherapy. His focus on immune cell dynamics, particularly the roles of γδ T cells and macrophages, promises to transform therapeutic strategies for both burn injuries and tumors. His ongoing research, including scarless wound healing regulation through novel technologies, signals his ongoing contributions to medical innovations. Looking ahead, Mr. Yang’s legacy will continue to inspire future research in immunology and regenerative medicine, with the potential for groundbreaking clinical applications.
Top Noted Publications 📖
Orchestration of Macrophage Polarization Dynamics by Fibroblast-Secreted Exosomes during Skin Wound Healing
Authors: Chen, C., Yang, J., Shang, R., Luo, G., He, W.
Journal: Journal of Investigative Dermatology
Year: 2025
Spatiotemporal Orchestration of Macrophage Activation Trajectories by Vγ4 T Cells during Skin Wound Healing
Authors: Hu, W., Zhang, X., Liu, Z., Luo, G., He, W.
Journal: iScience
Year: 2024
Comparison of Inferior Vena Cava Puncture Under Continuous Cardiac Perfusion with Cardiac Puncture in Blood Acquisition of the Laboratory Mouse
Authors: Hu, W., Sheng, H., Yang, J., Huang, C., Luo, G.
Journal: Laboratory Animals
Year: 2024
P311 Promotes IL-4 Receptor‒Mediated M2 Polarization of Macrophages to Enhance Angiogenesis for Efficient Skin Wound Healing
Authors: Chen, C., Tang, Y., Zhu, X., Luo, G., He, W.
Journal: Journal of Investigative Dermatology
Year: 2023
Dendritic Epidermal T Cells Secreting Exosomes Promote the Proliferation of Epidermal Stem Cells to Enhance Wound Re-Epithelialization
Authors: Liu, M., Liu, Z., Chen, Y., Luo, G., He, W.
Journal: Stem Cell Research and Therapy
Year: 2022