Ms. Natalia Herman-Sanchez | Bioinformatics | Young Scientist Award

University of Cordoba | Spain

PUBLICATION PROFILE

Orcid

👩‍🔬 INTRODUCTION

Natalia Hermán-Sánchez is a talented pre-doctoral researcher at the University of Córdoba, Spain. She is dedicated to advancing biomedical research, particularly in the study of liver diseases and cancer. Through her work, Hermán-Sánchez is exploring vital molecular processes, such as RNA splicing and SUMOylation, which play key roles in liver cancer development. As an FPU grant recipient, her contributions are shaping the future of scientific research in this critical area.

🎓 EARLY ACADEMIC PURSUITS

Natalia’s academic journey began with a strong foundation in biochemistry at the University of Córdoba, where she earned her Bachelor’s degree in 2020. She then pursued a Master’s degree in Translational Biomedical Research, completed in 2021, and also obtained a diploma in Bioinformatics Analysis from the University Pablo de Olavide in 2024. These accomplishments laid the groundwork for her deep dive into the molecular biology of cancer and liver diseases.

🧑‍💼 PROFESSIONAL ENDEAVORS

Since 2021, Hermán-Sánchez has been working as a pre-doctoral researcher at the University of Córdoba under the FPU grant program. Her professional focus has been centered on understanding liver diseases and hepatocellular carcinoma (HCC). She is specifically investigating the roles of RNA splicing factors and other molecular mechanisms involved in disease progression, with the aim of discovering novel biomarkers and therapeutic targets.

🔬 CONTRIBUTIONS AND RESEARCH FOCUS

Hermán-Sánchez’s research is at the forefront of liver disease and cancer research. She has contributed significantly to studies on RNA splicing, SUMOylation, and the post-transcriptional regulation of genes in liver cancer. Her work aims to uncover new diagnostic and prognostic markers, with several impactful publications in top-tier journals like Cell Reports and Experimental & Molecular Medicine. Through this research, she is shaping our understanding of liver cancer biology and offering potential pathways for clinical interventions.

🌍 IMPACT AND INFLUENCE

Hermán-Sánchez’s research is making waves in the scientific community, particularly in the study of liver cancer. Her work has been widely cited and has influenced ongoing research in cancer biology and liver diseases. By presenting her findings at major international conferences such as the European Association for the Study of the Liver (EASL), she is contributing to the global conversation on liver cancer and molecular oncology, solidifying her place as an emerging leader in the field.

📚 ACADEMIC CITATIONS AND PUBLICATIONS

Natalia’s growing list of scientific publications reflects her significant contributions to the fields of hepatology and cancer research. Her research on RNA splicing factors in hepatocellular carcinoma has gained significant attention in the scientific community. These publications underscore her potential as a rising star in biomedical research, with a focus on advancing our understanding of cancer and chronic liver diseases.

🏅 HONORS & AWARDS

Throughout her academic journey, Hermán-Sánchez has received recognition for her work, including invitations to present at prestigious scientific events. Her research has earned her several honors and awards, highlighting her potential as a future leader in biomedical research. Her presentations at conferences have been recognized for their scientific merit, showcasing her contributions to liver cancer research.

🌟 LEGACY AND FUTURE CONTRIBUTIONS

As she continues her research, Hermán-Sánchez is poised to make lasting contributions to the field of biomedical science. Her exploration of molecular mechanisms in liver cancer holds the potential to uncover new therapeutic strategies and diagnostic tools, benefiting patients worldwide. Her continued dedication to understanding the biology of liver diseases ensures that her future work will have a profound impact on clinical practices and cancer treatment.

💬 FINAL CONCLUSION

In summary, Natalia Hermán-Sánchez is a promising and impactful researcher whose work is helping to redefine our understanding of liver cancer and disease. Through her academic achievements, professional experience, and groundbreaking research, she is paving the way for new diagnostic and therapeutic approaches that could ultimately improve patient outcomes. Hermán-Sánchez’s future contributions to biomedical research and clinical medicine are poised to leave a lasting legacy in the fight against liver diseases and cancer.

📚 TOP NOTES PUBLICATIONS

PRPF8 increases the aggressiveness of hepatocellular carcinoma by regulating FAK/AKT pathway via fibronectin 1 splicing

- Authors: Juan L. López-Cánovas, Natalia Hermán-Sánchez, Mercedes del Rio-Moreno, Antonio C. Fuentes-Fayos, Araceli Lara-López, Marina E. Sánchez-Frias, Víctor Amado, Rubén Ciria, Javier Briceño, Manuel de la Mata et al.
- Journal: Experimental & Molecular Medicine
- Year: 2023-01-06

Spliceosomal profiling identifies EIF4A3 as a novel oncogene in hepatocellular carcinoma acting through the modulation of FGFR4 splicing

- Authors: Juan L. López‐Cánovas, Natalia Hermán‐Sánchez, Maria Trinidad Moreno‐Montilla, Mercedes del Rio‐Moreno, Emilia Alors‐Perez, Marina E. Sánchez‐Frias, Víctor Amado, Rubén Ciria, Javier Briceño, Manuel de la Mata et al.
- Journal: Clinical and Translational Medicine
- Year: 2022-11

Multidisciplinary Prehabilitation and Postoperative Rehabilitation for Avoiding Complications in Patients Undergoing Resection of Colon Cancer: Rationale, Design, and Methodology of the ONCOFIT Study

- Authors: Amaro-Gahete, FJ, Javier Jurado, Andrea Cisneros, Pablo Corres, Andres Marmol-Perez, Francisco J. Osuna-Prieto, Manuel Fernández-Escabias, Estela Salcedo, Natalia Hermán-Sánchez, Manuel D. Gahete et al.
- Journal: Nutrients
- Year: 2022-11-03

Dysregulation of splicing variants and spliceosome components in breast cancer

- Authors: Manuel D Gahete, Natalia Herman-Sanchez, Antonio C Fuentes-Fayos, Juan L Lopez-Canovas, Raúl M Luque
- Journal: Endocrine-Related Cancer
- Year: 2022-09-01

Morphofunctional and Molecular Assessment of Nutritional Status in Head and Neck Cancer Patients Undergoing Systemic Treatment: Role of Inflammasome in Clinical Nutrition

- Authors: Soraya León-Idougourram, Jesús M. Pérez-Gómez, Concepción Muñoz Jiménez, Fernando L-López, Gregorio Manzano García, María José Molina Puertas, Natalia Herman-Sánchez, Rosario Alonso-Echague, Alfonso Calañas Continente, María Ángeles Gálvez Moreno et al.
- Journal: Cancers
- Year: 2022-01-19

Dr. Neda Fayyazi | Bioinformatics | Excellence in Innovation

ogen/ medical iincubator, Iran

Author Profile 📚

Google Scholar

Early Academic Pursuits 🎓

Dr. Neda Fayyazi’s academic journey is marked by significant achievements, beginning with her Ph.D. in Pharmaceutical and Medicinal Chemistry from Isfahan University of Medical Sciences, which she completed between February 2015 and October 2019. Her outstanding academic performance earned her a top rank (A) with a GPA of 3.60. Dr. Fayyazi’s thesis, titled Molecular modeling, synthesis, and biological evaluation of hybrid multi-target iron chelators for anticancer and antimalarial applications, was highly regarded, securing an Excellent Rank (A). Her interdisciplinary focus on combining computational techniques and medicinal chemistry positions her as an emerging leader in the field.

Professional Endeavors 💼

Dr. Fayyazi’s professional experience spans academia and industry, with roles in pharmaceutical companies and research institutions. She has worked with leading organizations, including TPCO Holding, Pars Darou Pharmaceutical Company, and Barkat Holding. Her roles involved product development, technology transfer, and research in the areas of pharmaceutical formulations, softgel production, and drug discovery. As a board member of Ozhan Pharma Group and an active participant in various projects, Dr. Fayyazi continues to bridge the gap between scientific research and commercial application.

Contributions and Research Focus 🔬

Dr. Fayyazi’s research contributions are primarily in the field of Medicinal Chemistry, with a focus on drug design, molecular modeling, and hybrid molecule synthesis. Her work on molecular dynamics simulations and protein-ligand interactions using cutting-edge tools like Gromacs, GOLD, and Discovery Studio has been instrumental in advancing the understanding of drug interactions at the molecular level. Additionally, she is passionate about developing novel drug delivery systems, particularly in sustained-release formulations, and exploring natural products for therapeutic potential. Her research integrates AI and machine learning approaches in drug discovery, a testament to her forward-thinking methodology.

Impact and Influence 🌍

Dr. Fayyazi has had a significant impact on the pharmaceutical industry and academia through her work in drug discovery, technology transfer, and industry collaboration. Her expertise in bioassay-guided screening and cancer therapy research has led to breakthroughs in medicinal chemistry, especially in the development of multi-target anticancer agents. As a member of various prestigious associations such as the European Bioinformatics Association and the American Chemical Society, she has contributed to the global advancement of biotechnology and pharmaceutical sciences. Her work has garnered recognition, including a prize for innovative ideas in drug research at the Euro Chemistry Conference in Berlin (2019).

Academic Cites and Research Recognition 📑

Dr. Fayyazi’s academic publications and research outputs are highly cited in the fields of molecular modeling and pharmaceutical sciences. Her collaborations with research institutions and pharmaceutical companies have cemented her reputation as a thought leader in medicinal chemistry. Notably, her research on iron chelators and cancer treatment has positioned her as a pivotal figure in advancing drug discovery methodologies. Her work is frequently referenced in studies related to drug design, molecular dynamics, and natural product research.

Technical Skills and Expertise 🧑‍🔬

Dr. Fayyazi’s technical proficiency extends across a broad spectrum of advanced scientific methods and tools. She is highly skilled in QSAR (Quantitative Structure-Activity Relationship), molecular dynamics simulations, and protein-ligand interactions. Her ability to synthesize hybrid compounds, coupled with her expertise in computational chemistry and machine learning, allows her to investigate complex biochemical interactions and design novel therapeutic agents. Furthermore, her knowledge of Linux environments, scripting, and drug discovery processes in natural products underscores her broad technical competence.

Teaching Experience 📚

Dr. Fayyazi’s passion for teaching is evident in her role as an educator at Isfahan University of Medical Sciences, where she has taught undergraduate students in organic chemistry, pharmacology, and computational chemistry. She has also supervised and mentored numerous master’s and Ph.D. students in the fields of medicinal chemistry and bioassays. Her teaching methods emphasize interdisciplinary approaches, integrating cutting-edge technology and scientific research into practical applications.

Legacy and Future Contributions 🌟

Looking ahead, Dr. Fayyazi’s future contributions are poised to continue shaping the pharmaceutical and biotechnology sectors. Her ongoing projects in controlled release formulations, softgel technology transfer, and sustained-release drug delivery systems demonstrate her commitment to improving patient outcomes through innovative therapeutic solutions. As she works to bridge the gap between academic research and industry applications, Dr. Fayyazi aims to inspire the next generation of scientists and continue her impactful work in drug design and natural product research.

Honor and Awards 🏆

Dr. Fayyazi’s career has been punctuated with numerous accolades, including the Best Score in the National Entrance Exam for Pharmaceutical Projects in 2001, the Productivity Management Prize at Soha Pharmaceutical Company (2010), and the prestigious PhD Scholarship for Medicinal Chemistry at Isfahan University. These awards reflect her unwavering dedication to excellence and innovation in both academic and industrial settings.

Top Noted Publications 📖

Molecular dynamics simulation and 3D-pharmacophore analysis of new quinoline-based analogues with dual potential against EGFR and VEGFR-2

- Authors: N. Fayyazi, A. Fassihi, S. Esmaeili, S. Taheri, J.B. Ghasemi, L. Saghaie
- Journal: International Journal of Biological Macromolecules
- Year: 2020

Pharmacophore modeling, synthesis, scaffold hopping and biological β-Hematin inhibition interaction studies for anti-malaria compounds

- Authors: N. Fayyazi, S. Esmaeili, S. Taheri, F.F. Ribeiro, M.T. Scotti, L. Scotti, …
- Journal: Current Topics in Medicinal Chemistry
- Year: 2019

Molecular dynamics simulation, 3D-pharmacophore and scaffold hopping analysis in the design of multi-target drugs to inhibit potential targets of COVID-19

- Authors: N. Fayyazi, T. Mostashari-Rad, J.B. Ghasemi, M.M. Ardakani, F. Kobarfard
- Journal: Journal of Biomolecular Structure and Dynamics
- Year: 2022

Design, synthesis, in silico studies, and antiproliferative evaluations of novel indolin-2-one derivatives containing 3-hydroxy-4-pyridinone fragment

- Authors: P. Shirvani, N. Fayyazi, S. Van Belle, Z. Debyser, F. Christ, L. Saghaie, …
- Journal: Bioorganic & Medicinal Chemistry Letters
- Year: 2022

Phytochemical analysis and purification of chief components of Ononis spinosa

- Authors: N. Fayyazi, F. Naghibi, S. Taheri
- Journal: N/A
- Year: 2014

A new insight into the mechanism of loading of Granisetron, Naltrexone and Risperidone in poly (ortho ester) and poly (lactic-co-glycolic acid) as the controlled release drug

- Authors: L. Karami, N. Fayyazi, M. Akbari, A. Molaei-Baghbanan, M. Maaza
- Journal: Journal of Drug Delivery Science and Technology
- Year: 2024

Natalia Herman-Sanchez | Bioinformatics | Young Scientist Award