Matheus Sewastjanow-Silva | Cancer Clinical Trial | Excellence in Research

Dr. Matheus Sewastjanow-Silva | Cancer Clinical Trial | Excellence in Research

The University of Texas MD Anderson Cancer Center, United States

Author Profiles

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Early Academic Pursuits 📚

Dr. Matheus Sewastjanow-Silva’s academic journey began at the Federal University of Minas Gerais (UFMG), Brazil, where he completed his Doctor of Medicine (M.D.) degree from 2012 to 2018. During his time at UFMG, he participated in various internships, enhancing his medical expertise across multiple fields, including rural and family medicine, as well as specialized training in dermatology, plastic surgery, and transplant surgery. Additionally, Dr. Sewastjanow-Silva received specialized training at prestigious institutions like A.C. Camargo Cancer Center and Jackson Memorial Hospital, further refining his skills in oncology and surgical specialties.

Professional Endeavors 💼

Dr. Sewastjanow-Silva’s professional career spans various roles at renowned institutions. Currently, he serves as a Research Investigator at the University of Texas MD Anderson Cancer Center (07/2024-present), where he contributes significantly to Shirley Su’s research group in the Department of Head and Neck Surgery. His responsibilities include managing clinical studies/trials databases, manuscript writing, and data analysis, using advanced tools like RedCap, Epic/SlicerDicer, and Prometheus. His prior experience at MD Anderson under Jaffer Ajani’s lab focused on clinical studies and research related to gastrointestinal oncology, where he gained expertise in DNA/RNA extraction, cell culture, and Western Blotting. Additionally, he worked as a physician in several clinics in Brazil, handling outpatient family medicine and emergency care, including COVID-19 patients, displaying his broad clinical knowledge and commitment to patient care.

Contributions and Research Focus 🧬

Dr. Sewastjanow-Silva’s primary research interests lie in oncology, particularly in gastrointestinal cancer and head and neck surgery. Throughout his career, he has been involved in multiple research projects aimed at improving clinical outcomes through the analysis of clinical samples, patient enrollment, and database management. His work involves cutting-edge technologies for analyzing cancer treatment responses, molecular genetics, and experimental models. He has authored and contributed to numerous publications and poster presentations in notable conferences such as the AACR Meeting and ASCO GI, focusing on cancer research and surgical techniques.

Impact and Influence 🌍

Dr. Sewastjanow-Silva has had a significant impact on the field of oncology, particularly through his contributions to clinical research. As a research investigator, he is at the forefront of studying innovative cancer therapies and advancing clinical knowledge in head and neck surgery. He is a respected member of the scientific community, holding memberships in the American Association for Cancer Research (AACR) and the American Society of Clinical Oncology (ASCO). Furthermore, his leadership role in organizing multiple cancer and surgical conferences demonstrates his influence in the academic community, aiming to foster collaboration and drive advancements in cancer research.

Academic Cites 📑

Dr. Sewastjanow-Silva’s academic contributions have garnered recognition within the scientific community, exemplified by his presentations at prominent conferences and his active participation in research publications. His involvement in studies and research protocols has significantly contributed to understanding cancer treatment and surgical outcomes. As a member of the Sigma Xi Scientific Research Honor Society (2024), Dr. Sewastjanow-Silva’s academic citations reflect his growing influence in the field, with numerous abstract and manuscript submissions to journals and conferences.

Technical Skills ⚙️

Dr. Sewastjanow-Silva possesses a robust skill set in both clinical and laboratory settings. His technical expertise includes advanced knowledge in the use of clinical trial management systems like RedCap, Epic/SlicerDicer, and Prometheus. He is proficient in molecular biology techniques such as DNA/RNA extraction, qPCR, Western Blotting, and viral transfections. In addition, he is skilled in cell culture, tissue staining, flow cytometry, and immunohistochemistry. These technical skills allow him to engage in high-level research and clinical analysis, contributing to the progression of cancer therapy.

Teaching Experience 🎓

As a Teaching Assistant at UFMG, Dr. Sewastjanow-Silva mentored first-year medical students, contributing to the academic development of future healthcare professionals. His involvement in various student interest groups, such as those focused on dermatology, anesthesiology, and plastic surgery, highlights his leadership and teaching skills. His role as a coordinator for the Plastic Surgery Student Interest Group further underscores his commitment to fostering the next generation of medical experts.

Leadership and Future Contributions 🌟

Dr. Sewastjanow-Silva’s leadership experience is extensive, having coordinated multiple medical and scientific initiatives at UFMG, such as organizing national campaigns for cancer and burn awareness, as well as medical education activities. As he continues his career at MD Anderson, Dr. Sewastjanow-Silva’s contributions to cancer research and clinical oncology are expected to further elevate his influence. His future endeavors will likely include continuing groundbreaking research, developing novel therapeutic strategies, and further mentoring and educating students and young researchers. His deep commitment to the advancement of medical science and patient care will undoubtedly shape the future of oncology.

Legacy and Lasting Impact 🏆

Dr. Sewastjanow-Silva’s legacy will be defined by his consistent commitment to advancing the field of oncology and his contributions to cancer research and clinical care. Through his extensive work in both Brazil and the United States, he has bridged international research gaps and improved clinical practices. His awards, including the “Young Talent for Science” and honors from Sigma Xi, reflect the significant strides he has made. Looking ahead, Dr. Sewastjanow-Silva will continue to impact the global medical community through innovation, research, and education, shaping the future of cancer care worldwide.

 

📖 Top Noted Publications

Esophageal cancer: emerging therapeutics

Authors: JE Rogers, M Sewastjanow-Silva, RE Waters, JA Ajani

Journal: Expert Opinion on Therapeutic Targets

Year: 2022

Evolution of immune and stromal cell states and ecotypes during gastric adenocarcinoma progression

Authors: R Wang, S Song, J Qin, K Yoshimura, F Peng, Y Chu, Y Li, Y Fan, J Jin, …

Journal: Cancer Cell

Year: 2023

Epithelial SOX9 drives progression and metastases of gastric adenocarcinoma by promoting immunosuppressive tumour microenvironment

Authors: Y Fan, Y Li, X Yao, J Jin, A Scott, B Liu, S Wang, L Huo, Y Wang, R Wang, …

Journal: Gut

Year: 2023

 Challenges and prospects of patient-derived xenografts for cancer research

Authors: J Jin, K Yoshimura, M Sewastjanow-Silva, S Song, JA Ajani

Journal: Cancers

Year: 2023

 Integrated genomic profiling and modelling for risk stratification in patients with advanced oesophagogastric adenocarcinoma

Authors: D Hao, S He, K Harada, MP Pizzi, Y Lu, P Guan, L Chen, R Wang, …

Journal: Gut

Year: 2021

Chitchamai Ovatlarnporn | Drug development | Best Researcher Award

Assist Prof Dr. Chitchamai Ovatlarnporn | Drug development | Best Researcher Award

Assist Prof Dr. Chitchamai Ovatlarnporn at Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hatyai, Songkhla, Thailand

👨‍🎓Professional Profiles

🧑‍🏫 Early Academic Pursuits

Dr. Chitchamai Ovatlarnporn’s academic journey began with a solid foundation in pharmacy. She earned her Bachelor of Pharmacy (Second Honours) from Songkhla University in 1990. Building on this, she went on to pursue higher education internationally, receiving a Master’s Degree in Biotechnology from the University of Kent at Canterbury in 1993, and later obtaining a Ph.D. in Chemistry from the University of Ottawa in 2000. This educational progression laid the groundwork for her distinguished career in pharmaceutical sciences, particularly in the areas of drug delivery systems, medicinal chemistry, and biotechnology.

💼 Professional Endeavors

Dr. Ovatlarnporn’s professional career has been deeply intertwined with both academic and research excellence. She holds a prominent position as an Associate Professor at the Faculty of Pharmaceutical Sciences, Prince of Songkla University (PSU), Thailand. In addition to her teaching responsibilities, she is a pivotal figure in the Department of Pharmaceutical Chemistry at PSU, where she focuses on cutting-edge pharmaceutical research, particularly related to drug development and delivery systems. Over the years, she has successfully combined her roles as an educator, researcher, and consultant in various national and international research projects.

Her expertise extends to consulting for product development and research with projects like Move World Together and Tech2BiZ, reflecting her dynamic role in fostering innovation within the pharmaceutical and biotechnology industries.

🔬 Contributions and Research Focus

Dr. Ovatlarnporn’s research is diverse and far-reaching, focusing primarily on drug delivery systems, pharmaceutical chemistry, and biotechnology. One of her major research interests lies in the development of nanotechnology-based drug delivery systems, such as the preparation and evaluation of nanomicelles for enhanced solubility and bioavailability of poorly water-soluble drugs like curcumin and resveratrol.

She has also made significant contributions to pharmacological research, investigating the antioxidant, anti-inflammatory, and anticancer properties of various medicinal plants and their bioactive compounds. Her work also includes genetic engineering, the synthesis of novel compounds, and the utilization of biopolymers for targeted drug delivery systems, particularly in colon-specific drug delivery.

🌍 Impact and Influence

Dr. Ovatlarnporn’s work has had a significant impact on both the academic and pharmaceutical industries. Her research on tetrhydrocurcumins, curcumin derivatives, and chitosan-based drug delivery systems has opened new avenues for cancer therapy, chronic disease management, and sustainable biopharmaceutical innovations.

Her published works are frequently cited in high-impact journals such as Food Bioscience, Journal of Drug Delivery Science and Technology, and Molecules, making her an influential researcher in her field. Her studies on natural compounds such as Viola stocksii and Tiliacora triandra have advanced the scientific understanding of their pharmacological potentials, contributing to the growing body of knowledge in natural product-based drug development.

📚 Academic Cites & Recognition

Dr. Ovatlarnporn has authored and co-authored numerous peer-reviewed papers, making significant contributions to the fields of medicinal chemistry, pharmaceutical biotechnology, and drug delivery systems. Notable publications include:

  • “Evaluation of the Anti-Inflammatory, Antioxidant, and Cytotoxic Potential of Cardamine Amara L.” published in Frontiers in Chemistry (Impact Factor: 5.5).
  • “Insights into the remarkable attenuation of hen egg white lysozyme amyloid fibril formation mediated by biogenic gold nanoparticles” in the International Journal of Biological Macromolecules (Impact Factor: 8.2).
  • Research on Acanthus ebracteatus and its bioactive properties, published in Molecules.

Her work is widely recognized, with her publications frequently cited by fellow researchers and practitioners in the pharmaceutical sciences, demonstrating her high standing in the global research community.

🛠 Technical Skills

Dr. Ovatlarnporn is proficient in a wide range of technical skills essential to her research work. These include:

  • Nanotechnology and Drug Delivery Systems: Expertise in the preparation and evaluation of drug formulations, particularly nanomicelles and nanoemulsions.
  • Medicinal Chemistry: Deep knowledge of bioactive natural products, their chemical properties, and potential therapeutic applications.
  • Pharmacological Research: Extensive experience in designing and conducting in vitro and in vivo studies to assess the biological activity of plant-based compounds.
  • Analytical Techniques: Skilled in HPLC, GC-MS, NMR, and spectroscopic methods for the identification and quantification of bioactive compounds.
  • Molecular Docking & Computational Studies: Proficient in using in silico models for studying molecular interactions and optimizing drug efficacy.

👨‍🏫 Teaching Experience

As an academic leader at Prince of Songkla University, Dr. Ovatlarnporn has had a profound influence on shaping the next generation of pharmaceutical scientists. Her teaching areas cover various aspects of medicinal chemistry, drug delivery systems, biotechnology, and pharmaceutical technology. She is known for integrating cutting-edge research findings into her curriculum, ensuring that students are exposed to the latest advancements in the field. Her mentoring has inspired numerous graduate students, many of whom have gone on to achieve their own academic and professional successes.

🌱 Legacy and Future Contributions

Looking forward, Dr. Ovatlarnporn is committed to advancing research on nanotechnology and its applications in targeted drug delivery systems. She aims to further her work on sustainable biopharmaceutical innovations and natural product-based therapies, especially in cancer treatment and chronic disease management. Her research in collaboration with industry partners promises to continue to bridge the gap between academic research and commercial product development, ensuring that her contributions have lasting real-world impact.

In the future, Dr. Ovatlarnporn plans to focus on enhancing the bioavailability of natural bioactive compounds, developing more efficient drug delivery platforms, and promoting interdisciplinary collaborations within the fields of pharmacy, biotechnology, and medicine. Her continued dedication to research excellence and academic mentorship ensures her legacy will live on in both the scientific community and the generations of students she has mentored.