Jiao Kai | Data Science | Best Researcher Award

Prof Dr. Jiao Kai | Data Science | Best Researcher Award

Department of Stomatology, Tangdu Hospital, China

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👨‍⚕️ Prof. Dr. Jiao Kai - A Leading Expert In Stomatology

Early Academic Pursuits 🎓

Prof. Dr. Jiao Kai’s academic journey in stomatology began with a deep commitment to the field. He pursued higher education, ultimately becoming a doctoral supervisor. His early research laid the groundwork for his future breakthroughs, with a focus on oral medicine and temporomandibular joint disorders. Through rigorous training, he became an expert in the intricacies of oral health, reconstructive techniques, and joint disorders, propelling his career to new heights.

Professional Endeavors 💼

Currently, Prof. Dr. Jiao serves as the Director of the Department of Stomatology at Tangdu Hospital, Air Force Medical University. His role encompasses both clinical practice and leading research initiatives. In addition, he is the Branch Secretary and Director of the Oral Medicine Teaching and Research Section. As a Doctoral Supervisor and member of various esteemed professional organizations, his influence spans across national and international levels.

Contributions and Research Focus 🔬

Prof. Dr. Jiao’s research primarily targets the prevention, treatment, and regenerative reconstruction of temporomandibular joint disorders. Leading numerous high-level research projects, his groundbreaking work in regenerative techniques has advanced the understanding and treatment of joint disorders, focusing on enhancing patient outcomes. His contributions have garnered numerous awards and recognition for scientific progress in stomatology.

Impact and Influence 🌍

Prof. Dr. Jiao has left a significant mark on the field, with his research being cited over 3,200 times globally. He has earned recognition as a scientist in the top 2% worldwide. His work has shaped clinical practices and continues to influence stomatology, earning him a reputation as a global leader in his field. He is also a sought-after reviewer and editor for numerous prestigious journals.

Academic Cites 📚

Over the last five years, Prof. Dr. Jiao’s research has been cited more than 3,200 times, with over 20 of his papers having an impact factor (IF) greater than 10. His extensive body of work has set new benchmarks in oral medicine, influencing clinical practices and advancing the understanding of temporomandibular joint disorders.

Legacy and Future Contributions 🌱

Prof. Dr. Jiao’s legacy is rooted in innovation, mentorship, and exceptional research. His groundbreaking studies and pioneering therapeutic techniques have solidified his position as a global leader in stomatology. Committed to advancing temporomandibular joint disorder research, he remains dedicated to the development of regenerative treatments and fostering international collaborations for future advancements.

Awards and Recognitions 🏆

Prof. Dr. Jiao has received multiple accolades, including the prestigious First Prize from the Chinese Stomatological Association and for Scientific Progress in Shaanxi Province. He has been recognized as a Young Top Talent of the National "Ten Thousand Talents Program" and a Distinguished Young Scholar in Shaanxi Province for his outstanding contributions to research and innovation.

Patents and Technology Transfer 🛠️

Prof. Dr. Jiao has contributed significantly to applied science, holding 29 invention patents, with 16 attributed to him as the primary inventor. His patents have led to the commercialization of advanced technologies, contributing to the academic and industrial sectors with a total transfer value exceeding 10 million yuan.

Collaborations and Professional Memberships 🤝

Prof. Dr. Jiao’s collaborations with global experts such as Professor Xu Cao (Johns Hopkins University) and Professor Jiang Chang (Chinese Academy of Sciences) have enhanced his international influence. He holds leadership positions in several national and regional scientific organizations, including the Shaanxi Provincial Stomatological Association and the Shaanxi Oral Physicians Association, contributing to the progress of the field.

Books Published and Editorial Appointments 📖

Prof. Dr. Jiao has actively contributed to academic literature, participating in the compilation and translation of 12 books, and serving as the chief editor for four of them. His editorial roles in national and international journals reflect his dedication to advancing knowledge in the field of stomatology.

Areas of Research 🔍

His ongoing research focuses on the prevention, treatment, and regenerative regeneration of temporomandibular joint disorders, striving to develop innovative therapies that improve patient care and outcomes globally. His work continues to shape the future of stomatology and has made a lasting impact on medical practices worldwide.

Top Noted Publications 📖

Pathological mechanism of chondrocytes and the surrounding environment during osteoarthritis of temporomandibular joint

Authors: Li B, Guan G, Mei L, Jiao K, Li H

Journal: Journal of Cellular and Molecular Medicine

Year: 2021

Crosstalk between Bone and Nerves within Bone

Authors: Wan QQ, Qin WP, Ma YX, Shen MJ, Li J, Zhang ZB, Chen JH, Tay FR, Niu LN, Jiao K

Journal: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)

Year: 2021

Matrix stiffening by self-mineralizable guided bone regeneration

Authors: Li J, Yan JF, Wan QQ, Shen MJ, Ma YX, Gu JT, Gao P, Tang XY, Yu F, Chen JH et al.

Journal: Acta Biomaterialia

Year: 2021

miR-200-3p suppresses cell proliferation and reduces apoptosis in diabetic retinopathy via blocking the TGF-β2/Smad pathway

Authors: Xue L, Xiong C, Li J, Ren Y, Zhang L, Jiao K, Chen C, Ding P

Journal: Bioscience Reports

Year: 2020

The 14-3-3η/GSK-3β/β-catenin complex regulates EndMT induced by 27-hydroxycholesterol in HUVECs and promotes the migration of breast cancer cells.

Authors: Zhen J, Jiao K, Yang K, Wu M, Zhou Q, Yang B, Xiao W, Hu C, Zhou M, Li Z

Journal: Cell Biology and Toxicology

Year: 2020

Xibing Xu | Data Science | Best Researcher Award

Dr. Xibing Xu | Data Science | Best Researcher Award

Shenzhen Medical Academy of Research and Translation, China

Author Profiles

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Early Academic Pursuits 🎓

Dr. Xibing Xu’s academic journey began with a solid foundation in biological sciences, leading to his Master’s degree from Shandong University in 2012. His Master’s thesis focused on the two-component signal transduction systems of Streptomyces hygroscopicus. This foundational research sparked his interest in bacterial biology and set the stage for his doctoral studies at Sichuan University. Dr. Xu’s Ph.D. thesis, completed in 2015, centered on “Protein homeostasis regulation and ubiquitin-like systems in bacteria,” deepening his expertise in bacterial systems and protein regulation.

Professional Endeavors 💼

his Ph.D., Dr. Xu expanded his research horizons by embarking on various international and prestigious roles. In 2017-2018, he was awarded a visiting scholarship by the China Scholarship Council, enabling him to work as a visiting scholar at the Laboratoire de Microbiologie et Génétique Moléculaire (LMGM) in Toulouse, France. This experience enhanced his research capabilities and fostered a deeper understanding of bacterial molecular mechanisms. From 2020 to the present, Dr. Xu has served as a Postdoctoral Fellow at LMGM, where he leads the ANR project M-Tox, which investigates translational control by HigB1 and MenT toxins in Mycobacterium tuberculosis.

Contributions and Research Focus 🔬

Dr. Xu’s research is at the cutting edge of microbiology, focusing on bacterial growth inhibition mechanisms mediated by toxins in toxin-antitoxin systems. Specifically, his work on deleterious tRNA nucleotidyltransferase toxins, like MenT in Mycobacterium tuberculosis, has unveiled novel bacterial mechanisms that regulate translation and protein homeostasis. His research involves exploring the role of tRNA biology in bacterial growth control and the interaction between tRNA and toxin proteins, a focus that has the potential to inform future therapeutic strategies for bacterial infections. His expertise extends to RNA-seq, enzymology, and protein-RNA/DNA interactions, all of which contribute to a deeper understanding of bacterial survival and virulence.

Impact and Influence 🌍

Dr. Xu’s work has far-reaching implications in microbial Microbiologie and therapeutic development. By identifying key mechanisms that control bacterial growth through toxin-antitoxin systems, his research addresses critical challenges in combating drug-resistant bacterial infections. His investigations into tRNA biology have provided insights into how bacteria regulate protein synthesis, which could lead to the development of novel antimicrobial strategies. His innovative research has garnered attention within the scientific community, reflected in invitations to present at major international conferences such as the 29th International tRNA Conference in 2024.

Academic Citations 📚

Dr. Xu’s contributions to the field have not only enhanced scientific knowledge but have also been widely recognized and cited in academic publications. His work on toxin-antitoxin systems and tRNA nucleotidyltransferase toxins has attracted significant attention in the microbiology and biochemistry fields. As his research continues to influence studies on bacterial translation control, his citation index is expected to grow, cementing his reputation as an expert in bacterial growth regulation and antibiotic resistance mechanisms.

Technical Skills 🛠️

Dr. Xu possesses a broad array of technical skills in biochemistry and molecular biology, enabling him to conduct complex experimental research. He is proficient in RNA-seq library design and construction, protein-DNA/RNA interaction analysis, and toxin protein purification and activity assays. Additionally, he has extensive experience in cell-free transcription and translation assays, essential for studying the mechanistic details of translation regulation in bacteria. His technical prowess underpins the success of his innovative research in bacterial biology and protein homeostasis.

Teaching Experience 👨‍🏫

Dr. Xu has a strong track record in teaching and academic supervision. From 2015 to 2020, he taught various courses such as Medical Biology, Medical Genetics, and Medical Cell Biology at Henan University of Science and Technology. His teaching not only involved extensive classroom hours but also practical experimental courses, allowing students to gain hands-on experience in molecular biology techniques. Since 2024, Dr. Xu has been supervising Master’s students at the University Paul Sabatier in Toulouse, mentoring students on projects related to phage peptides and protein homeostasis in bacteria, ensuring the next generation of scientists is equipped with the necessary research skills.

Legacy and Future Contributions 🌟

Dr. Xu’s current and future research promises to continue his legacy of groundbreaking work in microbiology, particularly in the areas of bacterial toxin-antitoxin systems and translation control. As a postdoctoral fellow and researcher at LMGM, he is leading projects that could revolutionize our understanding of bacterial growth regulation, with direct applications in combating drug-resistant Mycobacterium tuberculosis. His ongoing research, mentorship, and commitment to expanding scientific knowledge will ensure that his contributions to the field of microbiology will continue to grow in impact and influence.

 Top Noted Publications 📖

Title: Inducible auto-phosphorylation regulates a widespread family of nucleotidyltransferase toxins

Authors: Tom J. Arrowsmith, Xibing Xu, Shangze, Ben Usher, Peter Stokes, Megan Guest, Agnieszka K. Bronowska, Pierre Genevaux, Tim R. Blower
Journal: Nature Communications
Year: 2024

Title: MenT nucleotidyltransferase toxins extend tRNA acceptor stems and can be inhibited by asymmetrical antitoxin binding

Authors: Xibing Xu, Ben Usher, C. Gutierrez, R. Barriot, T.J. Arrowsmith, X. Han, P. Redder, O. Neyrolles, T.R. Blower, P. Genevaux
Journal: Nature Communications
Year: 2023

Title: Substrate recognition and cryo-EM structure of the ribosome-bound TAC toxin of Mycobacterium tuberculosis

Authors: Moïse, Emmanuel Giudice, Xibing Xu, Hatice Akarsu, Patricia Bordes, Valérie Guillet, Donna-Joe Bigot, Nawel Slama, Gaetano D’Urso, Sophie Chat et al.
Journal: Nature Communications
Year: 2022

Title: ClpXP-mediated Degradation of the TAC Antitoxin is Neutralized by the SecB-like Chaperone in Mycobacterium tuberculosis

Authors: Pauline Texier, Patricia Bordes, Jyotsna Nagpal, Ambre Julie Sala, Moise Mansour, Anne-Marie Cirinesi, Xibing Xu, David Andrew Dougan, Pierre Genevaux
Journal: Journal of Molecular Biology
Year: 2021

Title: The ubiquitin-like modification by ThiS and ThiF in Escherichia coli

Authors: Xibing Xu, Tao Wang, Yulong Niu, Ke Liang, Yi Yang
Journal: International Journal of Biological Macromolecules
Year: 2019

Title: BAH1 an E3 Ligase from Arabidopsis thaliana Stabilizes Heat Shock Factor σ32 of Escherichia coli by Interacting with DnaK/DnaJ Chaperone Team

Authors: Xibing Xu, Ke Liang, Yulong Niu, Yan Shen, Xuedong Wan, Haiyan Li, Yi Yang
Journal: Current Microbiology
Year: 2018