Shenzhen Medical Academy of Research and Translation, China
orcid
Scopus
Early Academic Pursuits ๐
Dr. Xibing Xuโs academic journey began with a solid foundation in biological sciences, leading to his Master’s degree from Shandong University in 2012. His Master’s thesis focused on the two-component signal transduction systems of Streptomyces hygroscopicus. This foundational research sparked his interest in bacterial biology and set the stage for his doctoral studies at Sichuan University. Dr. Xuโs Ph.D. thesis, completed in 2015, centered on โProtein homeostasis regulation and ubiquitin-like systems in bacteria,โ deepening his expertise in bacterial systems and protein regulation.
Professional Endeavors ๐ผ
his Ph.D., Dr. Xu expanded his research horizons by embarking on various international and prestigious roles. In 2017-2018, he was awarded a visiting scholarship by the China Scholarship Council, enabling him to work as a visiting scholar at the Laboratoire de Microbiologie et Gรฉnรฉtique Molรฉculaire (LMGM) in Toulouse, France. This experience enhanced his research capabilities and fostered a deeper understanding of bacterial molecular mechanisms. From 2020 to the present, Dr. Xu has served as a Postdoctoral Fellow at LMGM, where he leads the ANR project M-Tox, which investigates translational control by HigB1 and MenT toxins in Mycobacterium tuberculosis.
Contributions and Research Focus ๐ฌ
Dr. Xuโs research is at the cutting edge of microbiology, focusing on bacterial growth inhibition mechanisms mediated by toxins in toxin-antitoxin systems. Specifically, his work on deleterious tRNA nucleotidyltransferase toxins, like MenT in Mycobacterium tuberculosis, has unveiled novel bacterial mechanisms that regulate translation and protein homeostasis. His research involves exploring the role of tRNA biology in bacterial growth control and the interaction between tRNA and toxin proteins, a focus that has the potential to inform future therapeutic strategies for bacterial infections. His expertise extends to RNA-seq, enzymology, and protein-RNA/DNA interactions, all of which contribute to a deeper understanding of bacterial survival and virulence.
Impact and Influence ๐
Dr. Xuโs work has far-reaching implications in microbial Microbiologie and therapeutic development. By identifying key mechanisms that control bacterial growth through toxin-antitoxin systems, his research addresses critical challenges in combating drug-resistant bacterial infections. His investigations into tRNA biology have provided insights into how bacteria regulate protein synthesis, which could lead to the development of novel antimicrobial strategies. His innovative research has garnered attention within the scientific community, reflected in invitations to present at major international conferences such as the 29th International tRNA Conference in 2024.
Academic Citations ๐
Dr. Xuโs contributions to the field have not only enhanced scientific knowledge but have also been widely recognized and cited in academic publications. His work on toxin-antitoxin systems and tRNA nucleotidyltransferase toxins has attracted significant attention in the microbiology and biochemistry fields. As his research continues to influence studies on bacterial translation control, his citation index is expected to grow, cementing his reputation as an expert in bacterial growth regulation and antibiotic resistance mechanisms.
Technical Skills ๐ ๏ธ
Dr. Xu possesses a broad array of technical skills in biochemistry and molecular biology, enabling him to conduct complex experimental research. He is proficient in RNA-seq library design and construction, protein-DNA/RNA interaction analysis, and toxin protein purification and activity assays. Additionally, he has extensive experience in cell-free transcription and translation assays, essential for studying the mechanistic details of translation regulation in bacteria. His technical prowess underpins the success of his innovative research in bacterial biology and protein homeostasis.
Teaching Experience ๐จโ๐ซ
Dr. Xu has a strong track record in teaching and academic supervision. From 2015 to 2020, he taught various courses such as Medical Biology, Medical Genetics, and Medical Cell Biology at Henan University of Science and Technology. His teaching not only involved extensive classroom hours but also practical experimental courses, allowing students to gain hands-on experience in molecular biology techniques. Since 2024, Dr. Xu has been supervising Masterโs students at the University Paul Sabatier in Toulouse, mentoring students on projects related to phage peptides and protein homeostasis in bacteria, ensuring the next generation of scientists is equipped with the necessary research skills.
Legacy and Future Contributions ๐
Dr. Xuโs current and future research promises to continue his legacy of groundbreaking work in microbiology, particularly in the areas of bacterial toxin-antitoxin systems and translation control. As a postdoctoral fellow and researcher at LMGM, he is leading projects that could revolutionize our understanding of bacterial growth regulation, with direct applications in combating drug-resistant Mycobacterium tuberculosis. His ongoing research, mentorship, and commitment to expanding scientific knowledge will ensure that his contributions to the field of microbiology will continue to grow in impact and influence.
ย Top Noted Publications ๐