Assoc Prof Dr. Lishu Guo | Insight Interlace | Best Researcher Award
Assoc Prof Dr. Lishu Guo at Columbia University, China
Profiles
Academic Background
Lishu Guo is an accomplished Associate Research Scientist at Columbia University, New York, specializing in mitochondrial bioenergetics and metabolic reprogramming. With a global academic and research background, Dr. Guo has contributed significantly to understanding mitochondrial dynamics and their implications in cancer and metabolic disorders.
Education
Dr. Guo earned a Ph.D. in Biomedical Science from the University of Padova, Italy, focusing on mitochondrial permeability transition and F-ATP synthase (2015-2018). She also holds a Master’s in Pharmacology from Lanzhou University, China (2012-2014), and a Bachelor’s in Medicine from Henan University, China (2008-2012).
Professional Experience
Dr. Guo is currently serving as an Associate Research Scientist at Columbia University’s Department of Anesthesiology (since August 2024). Previously, she worked as a Young Associate Researcher at the Greater Bay Area Institute of Precision Medicine, Fudan University, China (2022-2024) and as an Assistant Researcher at Tongji University’s School of Medicine, China (2019-2022). She also completed a Fellowship at the University of Padova (2018-2019) and started her career as an Assistant Researcher at Shanghai Haohai Biological Technology Co., Ltd. (2014-2015).
Research Interests
Dr. Guo’s research interests include mitochondrial channels and permeability transition, oxidative phosphorylation, F-ATP synthase dynamics, oxidative stress, calcium homeostasis, and metabolic reprogramming. She explores these areas to understand their roles in cellular function and disease mechanisms.
Awards and Funding
Dr. Guo has received funding from the Shanghai Sailing Program (2020-2023) and the Shanghai Tenth People’s Hospital (2021-2023).
Memberships
Dr. Guo is a member of the Shanghai Overseas Returned Scholars Association and the Guangzhou Overseas Returned Scholars Association.
Reviewer
Dr. Guo serves as a reviewer for several journals, including ACS Chemical Neuroscience, Biochemical Pharmacology, and Mitochondrial Communications.
Patents
Dr. Guo holds patents for MTCH2 in cancer treatment drugs related to iron death (2023) and a composition for enhancing immune function (2023).
Publications
Title: F-ATP synthase inhibitory factor 1 regulates metabolic reprogramming involving its interaction with c-Myc and PGC1α
- Author(s): Guo, L., Gu, Z.
- Journal: Frontiers in Oncology
- Year: 2023
Title: Mitochondrial ATP synthase inhibitory factor 1 interacts with the p53–cyclophilin D complex and promotes opening of the permeability transition pore
- Author(s): Guo, L.
- Journal: Journal of Biological Chemistry
- Year: 2022
Title: Mitochondria and the permeability transition pore in cancer metabolic reprogramming
- Author(s): Guo, L.
- Journal: Biochemical Pharmacology
- Year: 2021
Title: Arg-8 of yeast subunit e contributes to the stability of F-ATP synthase dimers and to the generation of the full-conductance mitochondrial megachannel
- Author(s): Guo, L., Carraro, M., Carrer, A., Bernardi, P., Lippe, G.
- Journal: Journal of Biological Chemistry
- Year: 2019
Title: Arginine 107 of yeast ATP synthase subunit g mediates sensitivity of the mitochondrial permeability transition to phenylglyoxal
- Author(s): Guo, L., Carraro, M., Sartori, G., Petronilli, V., Bernardi, P.
- Journal: Journal of Biological Chemistry
- Year: 2018