Xibing Xu | Data Science | Best Researcher Award

Dr. Xibing Xu | Data Science | Best Researcher Award

Shenzhen Medical Academy of Research and Translation, China

Author Profiles

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Scopus

Early Academic Pursuits 🎓

Dr. Xibing Xu’s academic journey began with a solid foundation in biological sciences, leading to his Master’s degree from Shandong University in 2012. His Master’s thesis focused on the two-component signal transduction systems of Streptomyces hygroscopicus. This foundational research sparked his interest in bacterial biology and set the stage for his doctoral studies at Sichuan University. Dr. Xu’s Ph.D. thesis, completed in 2015, centered on “Protein homeostasis regulation and ubiquitin-like systems in bacteria,” deepening his expertise in bacterial systems and protein regulation.

Professional Endeavors 💼

his Ph.D., Dr. Xu expanded his research horizons by embarking on various international and prestigious roles. In 2017-2018, he was awarded a visiting scholarship by the China Scholarship Council, enabling him to work as a visiting scholar at the Laboratoire de Microbiologie et Génétique Moléculaire (LMGM) in Toulouse, France. This experience enhanced his research capabilities and fostered a deeper understanding of bacterial molecular mechanisms. From 2020 to the present, Dr. Xu has served as a Postdoctoral Fellow at LMGM, where he leads the ANR project M-Tox, which investigates translational control by HigB1 and MenT toxins in Mycobacterium tuberculosis.

Contributions and Research Focus 🔬

Dr. Xu’s research is at the cutting edge of microbiology, focusing on bacterial growth inhibition mechanisms mediated by toxins in toxin-antitoxin systems. Specifically, his work on deleterious tRNA nucleotidyltransferase toxins, like MenT in Mycobacterium tuberculosis, has unveiled novel bacterial mechanisms that regulate translation and protein homeostasis. His research involves exploring the role of tRNA biology in bacterial growth control and the interaction between tRNA and toxin proteins, a focus that has the potential to inform future therapeutic strategies for bacterial infections. His expertise extends to RNA-seq, enzymology, and protein-RNA/DNA interactions, all of which contribute to a deeper understanding of bacterial survival and virulence.

Impact and Influence 🌍

Dr. Xu’s work has far-reaching implications in microbial Microbiologie and therapeutic development. By identifying key mechanisms that control bacterial growth through toxin-antitoxin systems, his research addresses critical challenges in combating drug-resistant bacterial infections. His investigations into tRNA biology have provided insights into how bacteria regulate protein synthesis, which could lead to the development of novel antimicrobial strategies. His innovative research has garnered attention within the scientific community, reflected in invitations to present at major international conferences such as the 29th International tRNA Conference in 2024.

Academic Citations 📚

Dr. Xu’s contributions to the field have not only enhanced scientific knowledge but have also been widely recognized and cited in academic publications. His work on toxin-antitoxin systems and tRNA nucleotidyltransferase toxins has attracted significant attention in the microbiology and biochemistry fields. As his research continues to influence studies on bacterial translation control, his citation index is expected to grow, cementing his reputation as an expert in bacterial growth regulation and antibiotic resistance mechanisms.

Technical Skills 🛠️

Dr. Xu possesses a broad array of technical skills in biochemistry and molecular biology, enabling him to conduct complex experimental research. He is proficient in RNA-seq library design and construction, protein-DNA/RNA interaction analysis, and toxin protein purification and activity assays. Additionally, he has extensive experience in cell-free transcription and translation assays, essential for studying the mechanistic details of translation regulation in bacteria. His technical prowess underpins the success of his innovative research in bacterial biology and protein homeostasis.

Teaching Experience 👨‍🏫

Dr. Xu has a strong track record in teaching and academic supervision. From 2015 to 2020, he taught various courses such as Medical Biology, Medical Genetics, and Medical Cell Biology at Henan University of Science and Technology. His teaching not only involved extensive classroom hours but also practical experimental courses, allowing students to gain hands-on experience in molecular biology techniques. Since 2024, Dr. Xu has been supervising Master’s students at the University Paul Sabatier in Toulouse, mentoring students on projects related to phage peptides and protein homeostasis in bacteria, ensuring the next generation of scientists is equipped with the necessary research skills.

Legacy and Future Contributions 🌟

Dr. Xu’s current and future research promises to continue his legacy of groundbreaking work in microbiology, particularly in the areas of bacterial toxin-antitoxin systems and translation control. As a postdoctoral fellow and researcher at LMGM, he is leading projects that could revolutionize our understanding of bacterial growth regulation, with direct applications in combating drug-resistant Mycobacterium tuberculosis. His ongoing research, mentorship, and commitment to expanding scientific knowledge will ensure that his contributions to the field of microbiology will continue to grow in impact and influence.

 Top Noted Publications 📖

Title: Inducible auto-phosphorylation regulates a widespread family of nucleotidyltransferase toxins

Authors: Tom J. Arrowsmith, Xibing Xu, Shangze, Ben Usher, Peter Stokes, Megan Guest, Agnieszka K. Bronowska, Pierre Genevaux, Tim R. Blower
Journal: Nature Communications
Year: 2024

Title: MenT nucleotidyltransferase toxins extend tRNA acceptor stems and can be inhibited by asymmetrical antitoxin binding

Authors: Xibing Xu, Ben Usher, C. Gutierrez, R. Barriot, T.J. Arrowsmith, X. Han, P. Redder, O. Neyrolles, T.R. Blower, P. Genevaux
Journal: Nature Communications
Year: 2023

Title: Substrate recognition and cryo-EM structure of the ribosome-bound TAC toxin of Mycobacterium tuberculosis

Authors: Moïse, Emmanuel Giudice, Xibing Xu, Hatice Akarsu, Patricia Bordes, Valérie Guillet, Donna-Joe Bigot, Nawel Slama, Gaetano D’Urso, Sophie Chat et al.
Journal: Nature Communications
Year: 2022

Title: ClpXP-mediated Degradation of the TAC Antitoxin is Neutralized by the SecB-like Chaperone in Mycobacterium tuberculosis

Authors: Pauline Texier, Patricia Bordes, Jyotsna Nagpal, Ambre Julie Sala, Moise Mansour, Anne-Marie Cirinesi, Xibing Xu, David Andrew Dougan, Pierre Genevaux
Journal: Journal of Molecular Biology
Year: 2021

Title: The ubiquitin-like modification by ThiS and ThiF in Escherichia coli

Authors: Xibing Xu, Tao Wang, Yulong Niu, Ke Liang, Yi Yang
Journal: International Journal of Biological Macromolecules
Year: 2019

Title: BAH1 an E3 Ligase from Arabidopsis thaliana Stabilizes Heat Shock Factor σ32 of Escherichia coli by Interacting with DnaK/DnaJ Chaperone Team

Authors: Xibing Xu, Ke Liang, Yulong Niu, Yan Shen, Xuedong Wan, Haiyan Li, Yi Yang
Journal: Current Microbiology
Year: 2018

Lucia Grumetto | Predictive Analytics | Best Researcher Award

Prof. Lucia Grumetto | Predictive Analytics | Best Researcher Award

Università di napoli Dipartimento di Farmacia, Italy

👨‍🎓 Author Profiles

🎓 Academic Foundations and Professional Development

Prof. Lucia Grumetto’s academic path began at the University of Naples Federico II, where she completed dual degrees in Pharmacy and Biological Sciences. Over her extensive career, she gained considerable experience as a Researcher, later advancing to Associate Professor in the same institution. Her qualifications are further reinforced by a Master’s Degree in Food Law (2014), underscoring her ability to integrate scientific knowledge with legal and regulatory expertise, particularly in food safety.

💼 Professional Endeavors and Expertise

Throughout her career, Prof. Grumetto has contributed significantly to both pharmaceutical research and education. Her professional journey spans multiple roles, including Researcher, Professor, and Consultant in the areas of toxicology, pharmacokinetics, and environmental health. She has been actively involved in key research initiatives aimed at understanding the behavior of endocrine disruptors in biological systems, including the human blood-brain barrier and ocular barriers. Her research projects on sustainable drug formulations and environmental monitoring are crucial in addressing both public health and ecological concerns.

🔬 Research Focus and Scientific Contributions

Prof. Grumetto’s research has a broad scope, ranging from drug development to environmental health. She has led investigations into the pharmacokinetics of pharmaceutical compounds, focusing on their absorption, distribution, and metabolism in different biological systems. Her work on the interaction of endocrine disruptors in food and environmental matrices has positioned her as a leading expert in toxicology. Notable projects include the study of pharmaceutical permeation through biological membranes and the development of novel drug delivery systems targeting cancer therapies. Her contributions have been widely recognized through numerous publications, awards, and collaborations with international research networks.

🌍 Impact on Academia and Scientific Communities

Prof. Grumetto has profoundly impacted the scientific community through her research, teaching, and publications. With over 80 peer-reviewed papers and presentations at global conferences, she has shared her expertise in pharmacokinetics, endocrine toxicology, and drug testing. Her work on endocrine disruptors has not only influenced academic research but also shaped policies on environmental safety and public health. Her Most Cited Paper Award from the European Journal of Pharmaceutical Sciences and the Best Poster Award at various symposia are testaments to her influence. Additionally, she serves on the Editorial Boards of several high-impact journals, further contributing to the academic world.

👩‍🏫 Teaching and Pedagogical Innovations

Prof. Grumetto is deeply committed to education, having taught various specialized courses at the University of Naples Federico II. Her courses, such as Quality Control and Food Safety Regulations and Xenobiotic Analysis, are integral parts of the curricula for students pursuing degrees in Nutraceutical Sciences and Pharmaceutical Sciences. Beyond her classroom responsibilities, she has taken on leadership roles in shaping internship programs and curricular development, ensuring students gain hands-on experience and the necessary skills to succeed in their professional careers.

🔧 Technical Expertise and Analytical Innovations

One of Prof. Grumetto’s strengths lies in her technical expertise, particularly in the field of analytical chemistry. Her pioneering work with HPLC, mass spectrometry, and immobilized artificial membranes (IAM) has significantly advanced pharmacokinetic research. She has developed innovative methodologies for studying drug interactions and their bioavailability, especially for substances that cross biological barriers like the blood-brain barrier. These techniques are essential for understanding drug absorption and improving drug delivery systems.

🏆 Recognition, Awards, and Achievements

Prof. Grumetto’s contributions have been recognized with numerous awards and honors. In addition to her Best Poster Awards at international conferences, she received the Most Cited Paper Award from the European Journal of Pharmaceutical Sciences. She holds several patents, including one for a dermatological patch test device to identify allergic reactions to medications. Her innovations have extended beyond the academic realm, influencing practical applications in medicine, environmental monitoring, and sustainability.

🚀 Future Contributions and Vision

Looking ahead, Prof. Grumetto continues to push boundaries in both pharmaceutical research and sustainability. Her current projects, such as FRUIPAD, aim to create biodegradable food packaging from fruit by-products, highlighting her commitment to both environmental sustainability and public health. Her ongoing studies in endocrine disruptors and drug delivery systems hold the potential to influence future healthcare strategies, particularly in personalized medicine and targeted therapies. As she continues to lead innovative projects and collaborate internationally, her future contributions will likely reshape the way pharmaceuticals and environmental health issues are addressed globally.

📖 Top Noted Publications

 The combined use of biological investigations, bio chromatographic and in silico methods to solve the puzzle of badge and its derivative’s toxicity
  • Authors: Ilaria Neri, Marialuisa Piccolo, Giacomo Russo, Maria Grazia Ferraro, Vincenzo Marotta, Rita Santamaria, Lucia Grumetto
    Journal: Chemosphere
    Year: 2024
Phenylalanine Butyramide: A Butyrate Derivative as a Novel Inhibitor of Tyrosinase
  • Authors: Ritamaria Di Lorenzo, Vincenzo Di Lorenzo, Teresa Di Serio, Adua Marzocchi, Lucia Ricci, Eleonora Vardaro, Giovanni Greco, Maria Maisto, Lucia Grumetto, Vincenzo Piccolo et al.
    Journal: International Journal of Molecular Sciences
    Year: 2024
Investigating the Effect of Surface Hydrophilicity on the Destiny of PLGA-Poloxamer Nanoparticles in an In Vivo Animal Model
  • Authors: Teresa Silvestri, Lucia Grumetto, Ilaria Neri, Maria De Falco, Sossio Fabio Graziano, Sara Damiano, Daniela Giaquinto, Lucianna Maruccio, Paolo de Girolamo, Fabrizio Villapiano et al.
    Journal: International Journal of Molecular Sciences
    Year: 2023
Dermocosmetic evaluation of a nutricosmetic formulation based on Curcuma
  • Authors: Ritamaria Di Lorenzo, Lucia Grumetto, Antonia Sacchi, Sonia Laneri, Irene Dini
    Journal: Phytotherapy Research
    Year: 2023
Validation of an LC-MS/MS Method for the Determination of Abscisic Acid Concentration in a Real-World Setting
  • Authors: Elisabetta Schiano, Ilaria Neri, Maria Maisto, Ettore Novellino, Fortuna Iannuzzo, Vincenzo Piccolo, Vincenzo Summa, Lucia Grumetto, Gian Carlo Tenore
    Journal: Foods
    Year: 2023