Dr. Xiaobin Ling | Data Science | Best Researcher Award

UMass Medical School | United States

Publication Profile

Orcid

👨‍🔬 Summary

Dr. Xiaobin Ling is a Postdoctoral Researcher at the RNA Therapeutics Institute, UMass Medical School, specializing in lncRNA structure and Cryo-EM. With a Ph.D. in Structural Biology from Fudan University, his work focuses on the mechanisms of RNA structures, molecular biology, and biophysics, with a strong emphasis on cryo-electron microscopy (Cryo-EM).

🧑‍🏫 Current Position

Postdoctoral Researcher
RNA Therapeutics Institute, UMass Medical School (2024–Present)

• Research on RNA structures, particularly long non-coding RNAs (lncRNAs).
• Focus on Cryo-EM techniques to elucidate RNA structural dynamics.

🎓 Education

Ph.D. in Structural Biology (2017–2023)
Fudan University, Shanghai, China

• Research: Mechanisms and regulation of microRNA biogenesis and lncRNA structure.
  Master’s in Chemical Biology (2013–2016)
  Xiamen University, Xiamen, China
• Research: Drug mechanisms targeting nuclear receptors.
  B.Sc. in Biotechnology (2008–2013)
  Jinggangshan University, Ji’an, China

💼 Professional Experience

Senior Research Assistant (2022–2023)
Cryo-EM Core Facility, Sichuan University, China

• Managed operations for Titan Krios G3i, Talos Arctica G2, and JEOL1400 microscopes.
• Applied Cryo-EM techniques for structural research.

Structural Biologist Researcher (2021–2022)
Runjia Pharmaceutical Technology Co., Ltd, Shanghai, China

• Investigated ADAR inhibitors and their functions.

Research Assistant (2016–2017)
South University of Science and Technology of China, Shenzhen, China

• Focused on microRNA biogenesis and its regulation.

📚 Academic Publications

Dr. Ling has authored numerous peer-reviewed publications in top journals, including Nature, Nature Structural & Molecular Biology, and Cell Reports. Notable works include:

1. Cryo-EM structure of a natural RNA nanocage (Nature, 2025)
2. Circularly permuted group II introns and their mechanisms (Nature Structural & Molecular Biology, 2025)
3. Human telomeric G-quadruplex DNA binding (BBA – Gene Regulatory Mechanisms, 2023)
4. ADAR inhibitors and their function (prepint, 2022)

💡 Technical Skills

• Cryo-EM: Expertise in cryo-electron microscopy for RNA and protein structural analysis.
• RNA Structure Analysis: Proficient in the study of RNA folding and dynamics.
• Molecular Biology: Strong background in RNA and DNA manipulation, including G-quadruplexes and microRNA biogenesis.
• Computational Tools: Skilled in structural bioinformatics and molecular modeling.

👨‍🏫 Teaching Experience

Dr. Ling has contributed to academic training and mentoring at multiple institutions, particularly in structural biology and RNA research.

🔬 Research Interests On Data Science

• Structural biology of RNA molecules, focusing on lncRNAs and their roles in gene regulation.
• Application of Cryo-EM to explore the structural dynamics of RNA and protein complexes.
• Investigating RNA-related therapeutic strategies, including the use of RNA nanocages and RNA-based drug delivery systems.

 📚 Top Notes Publications

Cryo-EM structure of a natural RNA nanocage

• • Authors: Xiaobin Ling*, Dmitrij Golovenko, Jianhua Gan, Jinbiao Ma*, Andrei A. Korostelev*, Wenwen Fang*
  • Journal: Nature
  • Year: 2025 (accepted)

Structures of a natural circularly permuted group II intron reveal mechanisms of branching and back-splicing

• • Authors: Xiaobin Ling*, Yuqi Yao*, Jinbiao Ma*
  • Journal: Nature Structural & Molecular Biology
  • Year: 2025

The mechanism of UP1 binding and unfolding of human telomeric G-quadruplex DNA

• • Authors: Xiaobin Ling#, Yuqi Yao#, Lei Ding, Jinbiao Ma*
  • Journal: Biochimica et Biophysica Acta (BBA) – Gene Regulatory Mechanisms
  • Year: 2023

DHX9 resolves G-quadruplex condensation to prevent DNA double-strand breaks

• • Authors: Juan Chen#, Xiaobin Ling#, Youshan Zhao#, Sheng Li, Manan Li, Hailian Zhao, Xianguang Yang, Chun-kang Chang, Jinbiao Ma*, Yuanchao Xue*
  • Journal: preprint
  • Year: 2022

Phytochrome B inhibits the activity of phytochrome-interacting factor 7 involving phase separation

• • Authors: Yu Xie, Wenbo Liu, Wenjing Liang, Xiaobin Ling, Jinbiao Ma, Chuanwei Yang, Lin Li*
  • Journal: Cell Reports
  • Year: 2023

Modular characterization of SARS-CoV-2 nucleocapsid protein domain functions in nucleocapsid-like assembly

• • Authors: Yan Wang#, Xiaobin Ling#, Jian Zou, Chong Zhang, Bingnan Luo, Yongbo Luo, Xinyu Jia, Guowen Jia, Minghua Zhang, Junchao Hu, Ting Liu, Yuanfeiyi Wang, Kefeng Lu, Dan Li, Jinbiao Ma*, Cong Liu*, Zhaoming Su*
  • Journal: Molecular Biomedicine
  • Year: 2023