UMass Medical School | United States
Publication Profile
👨🔬 Summary
Dr. Xiaobin Ling is a Postdoctoral Researcher at the RNA Therapeutics Institute, UMass Medical School, specializing in lncRNA structure and Cryo-EM. With a Ph.D. in Structural Biology from Fudan University, his work focuses on the mechanisms of RNA structures, molecular biology, and biophysics, with a strong emphasis on cryo-electron microscopy (Cryo-EM).
🧑🏫 Current Position
Postdoctoral Researcher
RNA Therapeutics Institute, UMass Medical School (2024–Present)
- Research on RNA structures, particularly long non-coding RNAs (lncRNAs).
- Focus on Cryo-EM techniques to elucidate RNA structural dynamics.
🎓 Education
Ph.D. in Structural Biology (2017–2023)
Fudan University, Shanghai, China
- Research: Mechanisms and regulation of microRNA biogenesis and lncRNA structure.
Master’s in Chemical Biology (2013–2016)
Xiamen University, Xiamen, China
- Research: Drug mechanisms targeting nuclear receptors.
B.Sc. in Biotechnology (2008–2013)
Jinggangshan University, Ji’an, China
💼 Professional Experience
Senior Research Assistant (2022–2023)
Cryo-EM Core Facility, Sichuan University, China
- Managed operations for Titan Krios G3i, Talos Arctica G2, and JEOL1400 microscopes.
- Applied Cryo-EM techniques for structural research.
Structural Biologist Researcher (2021–2022)
Runjia Pharmaceutical Technology Co., Ltd, Shanghai, China
- Investigated ADAR inhibitors and their functions.
Research Assistant (2016–2017)
South University of Science and Technology of China, Shenzhen, China
- Focused on microRNA biogenesis and its regulation.
📚 Academic Publications
Dr. Ling has authored numerous peer-reviewed publications in top journals, including Nature, Nature Structural & Molecular Biology, and Cell Reports. Notable works include:
- Cryo-EM structure of a natural RNA nanocage (Nature, 2025)
- Circularly permuted group II introns and their mechanisms (Nature Structural & Molecular Biology, 2025)
- Human telomeric G-quadruplex DNA binding (BBA – Gene Regulatory Mechanisms, 2023)
- ADAR inhibitors and their function (prepint, 2022)
💡 Technical Skills
- Cryo-EM: Expertise in cryo-electron microscopy for RNA and protein structural analysis.
- RNA Structure Analysis: Proficient in the study of RNA folding and dynamics.
- Molecular Biology: Strong background in RNA and DNA manipulation, including G-quadruplexes and microRNA biogenesis.
- Computational Tools: Skilled in structural bioinformatics and molecular modeling.
👨🏫 Teaching Experience
Dr. Ling has contributed to academic training and mentoring at multiple institutions, particularly in structural biology and RNA research.
- Structural biology of RNA molecules, focusing on lncRNAs and their roles in gene regulation.
- Application of Cryo-EM to explore the structural dynamics of RNA and protein complexes.
- Investigating RNA-related therapeutic strategies, including the use of RNA nanocages and RNA-based drug delivery systems.
📚 Top Notes Publications
Cryo-EM structure of a natural RNA nanocage
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- Authors: Xiaobin Ling*, Dmitrij Golovenko, Jianhua Gan, Jinbiao Ma*, Andrei A. Korostelev*, Wenwen Fang*
- Journal: Nature
- Year: 2025 (accepted)
Structures of a natural circularly permuted group II intron reveal mechanisms of branching and back-splicing
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- Authors: Xiaobin Ling*, Yuqi Yao*, Jinbiao Ma*
- Journal: Nature Structural & Molecular Biology
- Year: 2025
The mechanism of UP1 binding and unfolding of human telomeric G-quadruplex DNA
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- Authors: Xiaobin Ling#, Yuqi Yao#, Lei Ding, Jinbiao Ma*
- Journal: Biochimica et Biophysica Acta (BBA) – Gene Regulatory Mechanisms
- Year: 2023
DHX9 resolves G-quadruplex condensation to prevent DNA double-strand breaks
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- Authors: Juan Chen#, Xiaobin Ling#, Youshan Zhao#, Sheng Li, Manan Li, Hailian Zhao, Xianguang Yang, Chun-kang Chang, Jinbiao Ma*, Yuanchao Xue*
- Journal: preprint
- Year: 2022
Phytochrome B inhibits the activity of phytochrome-interacting factor 7 involving phase separation
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- Authors: Yu Xie, Wenbo Liu, Wenjing Liang, Xiaobin Ling, Jinbiao Ma, Chuanwei Yang, Lin Li*
- Journal: Cell Reports
- Year: 2023
Modular characterization of SARS-CoV-2 nucleocapsid protein domain functions in nucleocapsid-like assembly
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- Authors: Yan Wang#, Xiaobin Ling#, Jian Zou, Chong Zhang, Bingnan Luo, Yongbo Luo, Xinyu Jia, Guowen Jia, Minghua Zhang, Junchao Hu, Ting Liu, Yuanfeiyi Wang, Kefeng Lu, Dan Li, Jinbiao Ma*, Cong Liu*, Zhaoming Su*
- Journal: Molecular Biomedicine
- Year: 2023