Eric Holland | Big Data Analytics | Best Researcher Award

Prof Dr. Eric Holland, Big Data Analytics, Best Researcher Award

Prof Dr. Eric Holland at Fred Hutch Cancer Center, United States

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🌟 Summary

Eric Charles Holland is a distinguished researcher and academician specializing in neuro-oncology, currently serving as a Professor in the Human Biology Division at the Fred Hutchinson Cancer Research Center in Seattle, WA. With extensive experience spanning clinical practice and translational research, he has made significant contributions to understanding and treating brain tumors.

🎓 Education

Eric Charles Holland pursued an academic journey marked by excellence and dedication to biomedical sciences. He earned his Bachelor of Science degree in Chemistry from Miami University in Oxford, OH, from 1977 to 1981, setting a solid foundation in the fundamentals of chemical sciences. Continuing his academic pursuits, Holland completed his PhD in Biochemistry & Molecular Biology at the University of Chicago from 1981 to 1985, where he engaged deeply in the molecular mechanisms underlying biological processes. Following his PhD, he further expanded his expertise by obtaining an MD in Medicine from Stanford University between 1985 and 1990, thereby integrating clinical insights with his strong research background.

💼 Professional Experience

Eric Charles Holland is a distinguished figure in neuro-oncology with a robust professional trajectory spanning prestigious institutions and significant leadership roles. He currently holds the position of Professor in the Human Biology Division at the Fred Hutchinson Cancer Research Center in Seattle, WA, a role he has held since 2013. Previously, he served as the Director of the Nancy and Buster Alvord Brain Tumor Center at the University of Washington, Seattle, WA, from 2013 to 2019. Prior to that, he was an Attending Surgeon at Memorial Hospital for Cancer and Allied Diseases in New York, NY, from 2006 to 2013, where he also held an Associate Professorship at Cornell University from 2000 to 2006. His career is distinguished by his contributions to advancing neurosurgical techniques and his leadership in multidisciplinary research initiatives aimed at improving treatments for brain tumors.

🔬 Research Interests

Eric Charles Holland is renowned for his pioneering research in neuro-oncology, focusing particularly on gliomas, the most common type of brain tumor. His research spans from basic molecular biology to translational studies aimed at developing innovative therapies. Holland is deeply engaged in understanding the genetic and molecular mechanisms that drive glioma formation and progression, utilizing advanced techniques such as transgenic models to simulate human disease conditions. His work also delves into the complex interactions within the tumor microenvironment and their impact on treatment outcomes. Holland’s interdisciplinary approach integrates molecular biology, genetics, and clinical research, aiming to accelerate the translation of scientific discoveries into effective therapies for patients with brain tumors.

📖 Publication Top Noted

Paper Title: CSF-1R inhibition alters macrophage polarization and blocks glioma progression
    • Authors: Stephanie M Pyonteck, Leila Akkari, Alberto J Schuhmacher, Robert L Bowman, Lisa Sevenich, Daniela F Quail, Oakley C Olson, Marsha L Quick, Jason T Huse, Virginia Teijeiro, Manu Setty, Christina S Leslie, Yoko Oei, Alicia Pedraza, Jianan Zhang, Cameron W Brennan, James C Sutton, Eric C Holland, Dylan Daniel, Johanna A Joyce
    • Journal: Nature medicine
    • Year: 2013
Paper Title: A brain tumor molecular imaging strategy using a new triple-modality MRI-photoacoustic-Raman nanoparticle
    • Authors: Moritz F Kircher, Adam De La Zerda, Jesse V Jokerst, Cristina L Zavaleta, Paul J Kempen, Erik Mittra, Ken Pitter, Ruimin Huang, Carl Campos, Frezghi Habte, Robert Sinclair, Cameron W Brennan, Ingo K Mellinghoff, Eric C Holland, Sanjiv S Gambhir
    • Journal: Lecture Notes in Networks and Systems
    • Year: 2012
    •  citations: 1157
Paper Title: Genomic Analysis of Non-NF2 Meningiomas Reveals Mutations in TRAF7KLF4AKT1, and SMO
    • Authors: Victoria E Clark, E Zeynep Erson-Omay, Akdes Serin, Jun Yin, Justin Cotney, Koray Özduman, Timuçin Avşar, Jie Li, Phillip B Murray, Octavian Henegariu, Saliha Yilmaz, Jennifer Moliterno Günel, Geneive Carrión-Grant, Baran Yılmaz, Conor Grady, Bahattin Tanrıkulu, Mehmet Bakırcıoğlu, Hande Kaymakçalan, Ahmet Okay Caglayan, Leman Sencar, Emre Ceyhun, A Fatih Atik, Yaşar Bayri, Hanwen Bai, Luis E Kolb, Ryan M Hebert, S Bulent Omay, Ketu Mishra-Gorur, Murim Choi, John D Overton, Eric C Holland, Shrikant Mane, Matthew W State, Kaya Bilgüvar, Joachim M Baehring, Philip H Gutin, Joseph M Piepmeier, Alexander Vortmeyer, Cameron W Brennan, M Necmettin Pamir, Türker Kılıç, Richard P Lifton, James P Noonan, Katsuhito Yasuno, Murat Günel
    • Journal: Science
    • Year: 2013
    •  citations: 856
Paper Title: The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo
    • Authors:Jason T Huse, Cameron Brennan, Dolores Hambardzumyan, Boyoung Wee, John Pena, Sara H Rouhanifard, Cherin Sohn-Lee, Carlos Le Sage, Reuven Agami, Thomas Tuschl, Eric C Holland
    • Journal: Proceedings of the National Academy of Sciences
    • Year: 2009
    •  citations: 664
Paper Title: Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor response
  • Authors: Nicholas J Szerlip, Alicia Pedraza, Debyani Chakravarty, Mohammad Azim, Jeremy McGuire, Yuqiang Fang, Tatsuya Ozawa, Eric C Holland, Jason T Huse, Suresh Jhanwar, Margaret A Leversha, Tom Mikkelsen, Cameron W Brennan
  • Journal: Proceedings of the National Academy of Sciences
  • Year: 2012
  •  citations: 611

Serena Nik-Zainal | Big Data Analytics | Best Researcher Award

Prof. Serena Nik-Zainal, Big Data Analytics, Best Researcher Award

Professor at University of Cambridge, United Kingdom

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🎓 Education 

  • University of Cambridge
    • B.A. (hons) – First, Physiology, 1998
    • M.B., B.Chir., Medicine/Surgery, 2000
  • Royal College of Physicians
    • M.R.C.P., Medicine, 2003
  • Wellcome Trust Sanger Institute
    • Ph.D., Cancer Genomics, 2012
  • Royal College of Physicians Specialist Register
    • Certification, Clinical Genetics, 2013

🌟 Personal Statement 

After earning a first-class degree in preclinical science and a medical degree from the University of Cambridge, sponsored by Petroliam Nasional Berhad Malaysia (PETRONAS) and as a Fellow of the Cambridge Commonwealth Trust, I specialized in Clinical Genetics. I have been an Honorary Consultant in Clinical Genetics at Cambridge University Hospitals NHS Foundation Trust since February 2013. My Ph.D. at the Wellcome Sanger Institute in 2012 focused on using next-generation sequencing (NGS) technology to explore cancer, leading to significant advancements in understanding tumor biology and mutational signatures. My current research integrates computational and experimental approaches to advance cancer genomics, developing machine-learning-based clinical algorithms and participating in large-scale projects like the UK 100,000 Genomes Project.

🏢 Positions and Honors 

Positions and Employment

  • Medical Student, University of Cambridge (1995-2000)
  • Pre-registration House Officer, East Anglian Deanery (2001-2002)
  • Senior House Officer, Medicine, East Anglian Deanery (2002-2004)
  • Specialist Registrar in Clinical Genetics, East Anglian Deanery (2004-2009)
  • Wellcome Clinical Research Training Fellow, Wellcome Sanger Institute (2009-2012)
  • Specialist Registrar in Clinical Genetics, East Anglian Deanery (2012-2013)
  • Wellcome Intermediate Clinical Research Training Fellow, Wellcome Sanger Institute (2013-2017)
  • Career Development Fellow, Wellcome Sanger Institute (2014-2017)
  • CRUK Advanced Clinician Scientist, University of Cambridge (2017-2021)
  • NIHR Research Professor of Genomic Medicine and Bioinformatics, University of Cambridge (2021-present)

Professional Memberships and Other Experience

  • Member, British Society of Genetic Medicine (2013-present)
  • EACR Ambassador (2015-present)
  • Member, Various Scientific Advisory Boards and Committees (2017-present)
  • Honorary NHS Consultant in Clinical Genetics, Cambridge University Hospital (2013-present)

Honors

  • Fellow of the Academy of Medical Sciences UK (2023)
  • Foulkes Foundation Medal UK (2021)
  • Sir Francis Crick Medal and Lecture from the Royal Society UK (2021)
  • Highly-Cited Researcher’s List Clarivate (2020)
  • EMBO Elected Fellow (2020)
  • Dr Josef Steiner Cancer Research Award (2019)
  • CRUK Pioneer Award (2016)
  • William Bate Hardy Prize (2014)
  • CRUK Future Leaders Prize (2014)
  • Wellcome-Beit Prize (2013)
  • AACR Scholar-in-training Award (2013)
  • EACR Susan G. Komen Prize (2012)
  • Robin Winter Prize (2012)

📚 Research Support 

Ongoing Research Support

  • NHSE Driver Project (Jan 2023-Mar 2024)
  • Breast Cancer Research Foundation (Oct 2022-ongoing)
  • CRUK/NIH Grand Challenge eDyNAmic (Jun 2022-May 2027)
  • UKRI DARE Sprint Exemplar (Jan 2022-Oct 2022)
  • NIHR Research Professorship (Dec 2021-Nov 2026)
  • Basser Gray Foundation Award (Dec 2020-Nov 2024)
  • Josef Steiner Award (Jun 2019-May 2023)

Completed Research Support

  • CRUK Early Detection Project Award (Jun 2019-May 2023)
  • CRUK Grand Challenge Award (May 2017-Apr 2024)
  • CRUK Advanced Clinician Scientist Award (Feb 2017-Oct 2022)
  • CRUK Pioneer Award (Oct 2016-Nov 2020)
  • Wellcome Trust Strategic Award (Sept 2013-July 2019)
  • Wellcome-Beit Prize (May 2013-May 2018)
  • Wellcome Intermediate Clinical Research Fellowship (Feb 2013-Jan 2017)

Beyond science, I have shared insights on women in STEM and my journey as a physician-scientist through essays in renowned journals.

📖 Publication Top Noted:

Paper Title: The patterns and dynamics of genomic instability in metastatic pancreatic cancer
  • Authors: Peter J Campbell, Shinichi Yachida, Laura J Mudie, Philip J Stephens, Erin D Pleasance, Lucy A Stebbings, Laura A Morsberger, Calli Latimer, Stuart McLaren, Meng-Lay Lin, David J McBride, Ignacio Varela, Serena A Nik-Zainal, Catherine Leroy, Mingming Jia, Andrew Menzies, Adam P Butler, Jon W Teague, Constance A Griffin, John Burton, Harold Swerdlow, Michael A Quail, Michael R Stratton, Christine Iacobuzio-Donahue, P Andrew Futreal
  • Journal: Nature
  • Year:  2010
  • citations: 1560
Paper TitlePan-cancer analysis of whole genomes
  • Authors: Dendy Adanta, Imam Syofii, Dewi Puspita Sari, Apri Wiyono
  • Journal: Nature
  • Year:  2020
  •  citations: 1736
Paper TitleMutational signatures associated with tobacco smoking in human cancer
  • Authors:Ludmil B Alexandrov, Young Seok Ju, Kerstin Haase, Peter Van Loo, Iñigo Martincorena, Serena Nik-Zainal, Yasushi Totoki, Akihiro Fujimoto, Hidewaki Nakagawa, Tatsuhiro Shibata, Peter J Campbell, Paolo Vineis, David H Phillips, Michael R Stratton
  • Journal: Science
  • Year:  2016
  •  citations: 1034
Paper Title: Clock-like mutational processes in human somatic cells
  • Authors: Ludmil B Alexandrov, Philip H Jones, David C Wedge, Julian E Sale, Peter J Campbell, Serena Nik-Zainal, Michael R Stratton
  • Journal: Nature genetics
  • Year:  2015
  •  citations: 990
Paper TitleHeterogeneity of genomic evolution and mutational profiles in multiple myeloma
  • Authors: Niccolo Bolli, Hervé Avet-Loiseau, David C Wedge, Peter Van Loo, Ludmil B Alexandrov, Inigo Martincorena, Kevin J Dawson, Francesco Iorio, Serena Nik-Zainal, Graham R Bignell, Jonathan W Hinton, Yilong Li, Jose MC Tubio, Stuart McLaren, Sarah O’Meara, Adam P Butler, Jon W Teague, Laura Mudie, Elizabeth Anderson, Naim Rashid, Yu-Tzu Tai, Masood A Shammas, Adam S Sperling, Mariateresa Fulciniti, Paul G Richardson, Giovanni Parmigiani, Florence Magrangeas, Stephane Minvielle, Philippe Moreau, Michel Attal, Thierry Facon, P Andrew Futreal, Kenneth C Anderson, Peter J Campbell, Nikhil C Munshi
  • Journal: Nature communications
  • Year: 2014
  •  citations: 963

Esmail El-Fakharany – Innovation in Data Analysis – Best Researcher Award 

Prof. Esmail El-Fakharany - Innovation in Data Analysis - Best Researcher Award 

city of scientific research and technological applications - Egypt

Author Profile

Early Academic Pursuits

Prof. Esmail Mohammed El-Fakharany embarked on his academic journey with a strong foundation in the sciences, obtaining his Bachelor's degrees in Microbiology and Chemistry from esteemed institutions such as Al Azhar University and Mynofia University in Egypt. His passion for understanding the intricacies of microbial life led him to pursue further studies, culminating in a Diploma of Public Health in Microbiology and subsequent Master's and Ph.D. degrees in Microbiology from Al Azhar University.

During his academic pursuits, El-Fakharany demonstrated exceptional dedication and scholarly aptitude, evidenced by his excellent academic records and research endeavors. His Master's thesis focused on the antiviral activity of natural purified proteins, while his Ph.D. research delved into the study of antiviral activity in lactoferrin, showcasing his early commitment to exploring the potential of natural compounds in combating viral infections.

Professional Endeavors

Prof. El-Fakharany's professional journey has been marked by progressive roles within the City of Scientific Research and Technological Applications (SRTA-City), particularly within the Genetic Engineering and Biotechnology Research Institute. Starting as a Lab Specialist, he steadily climbed the academic ranks, serving as a Research Assistant, Assistant Professor, and ultimately, Associate Professor.

His tenure at SRTA-City has been characterized by significant contributions to research and academia, with a particular emphasis on microbiology, biotechnology, and cancer research. His roles have involved supervising both Master's and Ph.D. students, reflecting his commitment to nurturing the next generation of scientists.

Contributions and Research Focus

Prof. El-Fakharany's research portfolio spans a diverse array of topics, including antiviral agents, cancer therapeutics, immunology, and nanotechnology. His investigations into the antiviral properties of natural compounds have yielded promising results, as evidenced by numerous publications in reputable journals.

Of particular note is his pioneering work on the antiviral activity of lactoferrin-coated nanoparticles, which has significant implications for combatting viral infections such as COVID-19. Additionally, his studies on the development of novel anticancer agents and eco-friendly antimicrobial technologies underscore his commitment to addressing pressing global health challenges.

Accolades and Recognition

Prof. El-Fakharany's contributions to science have been recognized through prestigious awards and accolades, including the State Encouragement Award in Advanced Technologies from the Egyptian Academy of Science and Technology. Furthermore, his receipt of certificates for research contributions and scientific achievements underscores the impact of his work within the scientific community.

Impact and Influence

Prof. El-Fakharany's research has made a tangible impact on scientific knowledge and has the potential to translate into practical solutions for societal challenges. His publications in esteemed journals and participation in funded research projects attest to the relevance and significance of his findings in fields such as virology, cancer biology, and environmental science.

Legacy and Future Contributions

As El-Fakharany continues to pursue excellence in research and academia, his legacy is poised to endure through the students he has mentored, the discoveries he has made, and the innovations he has championed. His ongoing dedication to advancing scientific knowledge and addressing global health concerns ensures that his contributions will continue to shape the trajectory of scientific inquiry for years to come.