Beijing Tiantan Hospital | China
PUBLICATION PROFILE
🎓 EARLY ACADEMIC PURSUITS
Dr. Lin Shi began her medical education at Harbin Medical University, where she earned both her M.D. and M.M. in Clinical Medicine between 2002 and 2009 under the mentorship of Professor Yunfu Cui. Building on this strong foundation, she pursued a Ph.D. in Neurosurgery at Capital Medical University from 2012 to 2015, under the guidance of Professor Zhongcheng Wang. Her academic background laid the groundwork for a career that would bridge clinical excellence with cutting-edge research in functional neurosurgery.
🩺 PROFESSIONAL ENDEAVORS
Dr. Shi’s clinical and academic career spans over 15 years, with progressive roles in major medical institutions. She started as a neurosurgeon at Beijing Haidian Hospital and soon joined Beijing Tiantan Hospital in 2015, where she advanced from neurosurgeon to attending neurosurgeon and eventually to associate senior neurosurgeon and associate professor by 2019. She also broadened her expertise during a visiting scholar appointment at Stanford University’s Center for Neurological Disorders. Throughout her career, she has taken leadership roles in numerous research projects funded by the National Natural Science Foundation of China and the Beijing Municipal Government, while also serving as an expert reviewer and editorial board member in both national and international scientific communities.
🧠 CONTRIBUTIONS AND RESEARCH FOCUS
Dr. Shi has made significant contributions in the field of functional brain disorders, which include conditions such as Parkinson’s disease, epilepsy, dystonia, and other rare neurological disorders. Since 2012, she has worked at the forefront of functional neurosurgery, especially in the areas of deep brain stimulation (DBS) and vagus nerve stimulation. Her research has focused on creating a comprehensive neuromodulation therapy system, including the development of a large-scale clinical database of over 5,000 cases, enabling better analysis and understanding of various brain disorders. She has also led mechanism-based studies on epilepsy, exploring inflammation, neurodegeneration, and neural circuitry using advanced animal models and molecular techniques.
🔬 RESEARCH MILESTONES
Dr. Shi’s research includes landmark studies that have advanced our understanding of epilepsy and DBS therapy. She created reliable animal models of temporal lobe epilepsy and demonstrated that anterior thalamic nucleus (ANT) stimulation offers neuroprotective effects by modulating inflammatory responses and promoting autophagy. At Stanford, she explored the functional connectivity of the brain through electrical stimulation, uncovering links between episodic memory and cortical network architecture—research published in Nature Human Behaviour. She also contributed to the expansion of neuromodulation indications by testing new neural targets and stimulation parameters, which provided key insights into delayed therapeutic responses in movement disorders like Parkinson’s disease.
🏅 IMPACT AND INFLUENCE
Dr. Shi’s influence in neurosurgery and neuroscience is widely recognized. She has led or participated in major research projects supported by the Beijing Natural Science Foundation and the NSFC, and has won numerous awards, including the Mao Yisheng Science and Technology Award and Beijing Youth Science and Technology Award. Her contributions to the development of China’s first domestically approved neurosurgical robot greatly enhanced the accuracy of DBS, reducing surgical error margins from 1.7mm to 0.6mm and enabling safer, faster procedures. The robot system she helped design has now been used in thousands of operations across top hospitals in China, generating significant economic and clinical value.
📚 ACADEMIC CITES AND RECOGNITION
Dr. Shi has authored more than 20 peer-reviewed SCI papers, with a cumulative impact factor exceeding 110. Notable publications include a study in JAMA Neurology (IF 18.3) on evolving intracranial lesions and a collaborative paper in Nature Human Behaviour (IF 13.7) that examined the cognitive effects of brain stimulation. Her research has been cited extensively and has received accolades from leading figures in neuroscience, such as Prof. Christof Koch. Additionally, she serves as a reviewer for several SCI journals and is active in multiple academic committees and expert panels in China.
🧬 LEGACY AND FUTURE CONTRIBUTIONS
Looking ahead, Dr. Shi aims to continue pushing the boundaries of neuromodulation therapy. She plans to integrate AI and robotics more deeply into neurosurgical practice, expand the use of DBS in psychiatric and rare neurological diseases, and refine patient-specific treatment algorithms using data from her extensive clinical database. Her vision includes bridging translational neuroscience with real-world application through collaboration with biomedical engineers, AI specialists, and international research institutions. With a strong portfolio of patents, publications, and clinical innovations, Dr. Shi is set to leave a lasting legacy in the treatment of functional brain disorders.
🧾 HONORS, PATENTS, AND GRANT HIGHLIGHTS
Dr. Shi holds five national patents, including devices designed for surgical precision and MRI safety. She has led over five major research projects, including the development of an automated navigation system for DBS and studies on novel neurostimulation targets, with total funding exceeding ¥2 million. Her published work spans top-tier journals such as JAMA Neurology, Brain Stimulation, and CNS Neuroscience & Therapeutics. Recognized as a leading voice in functional neurosurgery, she continues to shape the future of neuroscience in China and beyond.
📚 TOP NOTES PUBLICATIONS
1. Fronto-parieto-subthalamic activity decodes motor status in Parkinson’s disease
-
Authors: Zhang, Q.; Xie, H.; Zhao, B.; Yin, Z.; Liu, Y.; Liu, D.; Bai, Y.; Zhu, G.; Qin, G.; Gan, Y. et al.
-
Journal: CNS Neuroscience and Therapeutics
-
Year: 2023
2. Pallidal activities during sleep and sleep decoding in dystonia, Huntington’s, and Parkinson’s disease
-
Authors: Yin, Z.; Jiang, Y.; Merk, T.; Neumann, W.-J.; Ma, R.; An, Q.; Bai, Y.; Zhao, B.; Xu, Y.; Fan, H. et al.
-
Journal: Neurobiology of Disease
-
Year: 2023
3. Identification of Cuproptosis Clusters and Integrative Analyses in Parkinson’s Disease
4. Deep Brain Stimulation Electrode Reconstruction: Comparison between Lead-DBS and Surgical Planning System
5. Comparison of dural puncture and dural incision in deep brain stimulation surgery: A simple but worthwhile technique modification
-
Authors: Fan, S.; Zhang, Q.; Meng, F.; Fang, H.; Yang, G.; Shi, Z.; Liu, H.; Zhang, H.; Yang, A.; Zhang, J. et al.
-
Journal: Frontiers in Neuroscience
-
Year: 2022