Martin Hegen | Human Dose Predictions | Best Researcher Award

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Dr. Martin Hegen | Human Dose Predictions | Best Researcher Award

Pfizer | United States

PUBLICATION PROFILE

Scopus

🧑‍🔬 INTRODUCTION

Dr. Martin Hegen is a highly accomplished Research Fellow at Pfizer, widely respected for his leadership and scientific expertise in immunology and inflammation. With more than 20 years of experience in the pharmaceutical industry, Dr. Hegen has made substantial contributions to drug discovery and development, driving projects from portfolio entry to clinical proof-of-concept. His work bridges rigorous scientific research with strategic leadership, ensuring high-quality results and consistent compliance with regulatory and ethical standards.

🎓 EARLY ACADEMIC PURSUITS

Dr. Hegen began his academic journey in Germany, earning a Ph.D. in Immunology magna cum laude from Johannes Gutenberg-University of Mainz in 1993, after receiving an M.Sc. in Biology in 1988. He then undertook a postdoctoral fellowship at the Dana-Farber Cancer Institute, Harvard Medical School, where he explored critical signaling mechanisms in T cell activation involving CD26 and CD45 isoforms. This foundational research into immune system regulation shaped his scientific perspective and laid the groundwork for a successful career in translational immunology.

🧪 PROFESSIONAL ENDEAVORS

Dr. Hegen’s professional career spans over two decades of increasing responsibility and impact. He joined Wyeth Research in 2001, focusing on inflammatory diseases and advancing several therapeutic antibody programs. Following Pfizer’s acquisition of Wyeth in 2009, Dr. Hegen transitioned into the Inflammation & Immunology Research Unit at Pfizer, where he held several key roles including Senior Principal Scientist, Associate Research Fellow, and currently, Research Fellow. Throughout these positions, he provided scientific and managerial leadership for autoimmune disease models, led project teams, and mentored research scientists, including Ph.D.-level staff. He has directed collaborative programs across international sites and partnered with academic and biotech institutions to accelerate therapeutic innovation.

🔬 CONTRIBUTIONS AND RESEARCH FOCUS

Dr. Hegen’s scientific contributions are focused on autoimmune and inflammatory diseases, such as rheumatoid arthritis, lupus, psoriasis, inflammatory bowel disease, and multiple sclerosis. His expertise includes the use of gene-deficient mice and other advanced preclinical models to validate therapeutic targets. He has led efforts in both biologic and small molecule programs, guiding lead molecule selection and supporting successful clinical trials. His deep understanding of disease pathogenesis and experience with regulatory filings has been vital in bringing investigational drugs like Tofacitinib through the pipeline.

🌍 IMPACT AND INFLUENCE

Throughout his career, Dr. Hegen has left a lasting impact through both scientific contributions and leadership. Under his supervision, multiple scientists have received Individual Performance Awards. His strategic guidance and scientific rigor have influenced key decision-making processes, from target prioritization to portfolio entry and in-licensing evaluations. His work on clinical programs such as Ozoralizumab and other Janus kinase inhibitors has directly shaped Pfizer’s therapeutic portfolio in immunology.

📚 ACADEMIC CITATIONS AND PUBLICATIONS

Dr. Hegen has a strong publication record and has served on editorial boards for leading journals such as The Journal of Immunology, Inflammation Research, and Journal of Leukocyte Biology. He has contributed peer reviews and editorial oversight for decades, influencing scholarly standards in immunology and inflammation research. His expertise is frequently sought after in reviewing cutting-edge scientific findings, and he has held roles as associate editor and invited chairman at international immunology conferences.

🏆 HONORS & AWARDS

Dr. Hegen’s achievements have been recognized by prestigious organizations. He received a postdoctoral fellowship from the German Research Society and was honored with Wyeth’s “Above and Beyond Award” in 2003. He was selected for elite leadership training programs at Wyeth (Eagles Program) and Pfizer (Cornerstones of Management), highlighting his commitment not only to science but also to cultivating leadership excellence.

🧬 PATENTS

Dr. Hegen is listed as an inventor on multiple patents, emphasizing his role in therapeutic innovation. These include methods for using antibodies against IL-22, anti-M-CSF antibodies for treating inflammatory disorders, and the development of modified single-domain antibody molecules targeting TNF-α. His patents contribute to the intellectual property backbone supporting Pfizer’s clinical development programs.

🔮 LEGACY AND FUTURE CONTRIBUTIONS

Dr. Martin Hegen’s legacy is defined by scientific excellence, impactful leadership, and the successful advancement of multiple therapeutic programs. His work has significantly contributed to the understanding and treatment of complex autoimmune diseases. As an active member of the American College of Rheumatology and American Association of Immunologists, he continues to shape the future of immunology research. Dr. Hegen remains committed to mentoring the next generation of scientists and driving forward innovations that will improve patient care worldwide.

📝 FINAL NOTE

Dr. Martin Hegen represents the highest standard of professionalism, scientific insight, and collaborative leadership in biomedical research. His career reflects a rare combination of deep academic training, pharmaceutical innovation, and strategic execution. As immunology continues to evolve, Dr. Hegen’s enduring influence will be felt in both clinical outcomes and the growing body of scientific knowledge advancing human health.

 📚 TOP NOTES PUBLICATIONS

Cure as a treatment target in rheumatoid arthritis and systemic sclerosis—achievable aim or mission impossible? FOREUM stimulates new industry-academia collaboration

    • Authors: Kenneth F. Baker, J. Spierings, Martin Brom, Stephen Oliver, Richard Veselý

    • Journal: Rheumatology (exact journal not specified, likely from context)

    • Year: (Not explicitly provided, but likely 2023 or 2024)

RORγt inhibition ameliorates IL-23 driven experimental psoriatic arthritis by predominantly modulating γδ-T cells

    • Authors: Céline Mortier, Eric Gracey, Julie Coudenys, Dirk Elewaut, Koen J.T. Venken

    • Journal: Rheumatology

    • Year: 2023

A Novel C-C Chemoattractant Cytokine (Chemokine) Receptor 6 (CCR6) Antagonist (PF-07054894)…
(Truncated title: “…Distinguishes between Homologous Chemokine Receptors, Increases Basal Circulating CCR6⁺ T Cells, and Ameliorates Interleukin-23-Induced Skin Inflammation”)

    • Authors: Wei Li, Kimberly K. Crouse, Jennifer Alley, Michael S. Vincent, Gabriel Berstein

    • Journal: Journal of Pharmacology and Experimental Therapeutics

    • Year: 2023

Studies with neutralizing antibodies suggest CXCL8-mediated neutrophil activation is independent of C-C motif chemokine receptor-like 2 (CCRL2) ligand binding function

    • Authors: Zhenwei Su, Jonathan M. Brooks, Jeffrey W. Pelker, Alfredo Darmanin Sheehan, Joseph J. Brennan

    • Journal: PLoS ONE

    • Year: 2023

Jinpeng Chen | recommendation systems | Best Researcher Award

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Assoc Prof Dr. Jinpeng Chen | recommendation systems | Best Researcher Award

Beijing University of Posts & Telecommunications | China

Publication Profile

Google Scholar

Biography of Assoc Prof Dr. Jinpeng Chen 👨‍💻

🎓 Education & Global Experience

Assoc. Prof. Dr. Jinpeng Chen began his academic journey with a Ph.D. in Computer Science from Beihang University (2011–2016). During his doctoral studies, he expanded his research horizons internationally—spending a year as a Visiting Ph.D. scholar at Aalborg University in Denmark (2014–2015), and also working as a Research Assistant at the University of Sydney in Australia (2013–2014). These global experiences laid the foundation for his collaborative and cross-cultural approach to research. 🌍📘

👨‍🏫 Academic Positions

Dr. Chen currently serves as an Associate Professor at the Beijing University of Posts and Telecommunications (BUPT), a position he has held since December 2018. Prior to that, he was an Assistant Professor at BUPT from 2016 to 2018. Over the years, he has been actively involved in teaching, mentoring graduate students, and leading innovative research projects. 🏫🔬

🔬 Research Interests & Projects

His research primarily focuses on Data Mining, Social Network Analysis, Crowdsourcing-based Data Processing, Machine Learning, and Artificial Intelligence. Dr. Chen has led and contributed to numerous high-impact research projects, including the Beijing Natural Science Foundation (2023–2026) and multiple grants from the National Natural Science Foundation of China. He also participated in the National Key R&D Program of China, contributing to the development of algorithms for user profiling, recommendations, traffic analysis, and intelligent marketing. 📊🤖

🧠 Academic Service & Community Contribution

Dr. Chen is a dedicated member of the global research community. He has served as a reviewer for prestigious journals such as ACM TOIS, TKDD, IEEE TNNLS, IEEE TFS, and TCC, among others. He is also a frequent external reviewer and program committee member for leading conferences like KDD, WWW, DASFAA, IJCAI, and BigData. His expert insights and evaluations have helped maintain the high standards of academic publishing. 📝🌐

🎤 Talks & Presentations

As a recognized thought leader in his field, Dr. Chen has been invited to speak at major academic events. Notable presentations include his talk at the KDD China 2023 Summer School on “Mandari: Multi-Modal Temporal Knowledge Graph-aware Sub-graph Embedding”, and his keynote at ICAIBD 2023 on “Sequential Intention-aware Recommender based on User Interaction Graph”. He has also shared his research at CGCM 2014 and during a special invitation to the School of Information Technologies at the University of Sydney. 🗣️📢

🚀 Impact & Vision

Assoc. Prof. Dr. Jinpeng Chen continues to drive innovation at the intersection of data science and artificial intelligence. His research not only contributes to academic advancement but also influences real-world applications in technology, business, and social platforms. With a passion for AI and a strong foundation in collaborative research, he is shaping the future of intelligent systems, one algorithm at a time. 🌟📈

📚 Top Notes Publications

Title: Automatic tagging by leveraging visual and annotated features in social media

Authors: J. Chen, P. Ying, X. Fu, X. Luo, H. Guan, K. Wei
Journal: IEEE Transactions on Multimedia
Year: 2021

Title: Inferring tag co-occurrence relationship across heterogeneous social networks

Authors: J. Chen, Y. Liu, G. Yang, M. Zou
Journal: Applied Soft Computing
Year: 2018

Title: Sequential intention-aware recommender based on user interaction graph

Authors: J. Chen, Y. Cao, F. Zhang, P. Sun, K. Wei
Journal: Proceedings of the 2022 International Conference on Multimedia Retrieval
Year: 2022

Title: From tie strength to function: Home location estimation in social network

Authors: J. Chen, Y. Liu, M. Zou
Journal: 2014 IEEE Computers, Communications and IT Applications Conference
Year: 2014

Title: FePN: A robust feature purification network to defend against adversarial examples

Authors: D. Cao, K. Wei, Y. Wu, J. Zhang, B. Feng, J. Chen
Journal: Computers & Security
Year: 2023