Xiaobin Ling | Data Science | Best Researcher Award

Dr. Xiaobin Ling | Data Science | Best Researcher Award

UMass Medical School | United States

Publication Profile

Orcid

👨‍🔬 Summary

Dr. Xiaobin Ling is a Postdoctoral Researcher at the RNA Therapeutics Institute, UMass Medical School, specializing in lncRNA structure and Cryo-EM. With a Ph.D. in Structural Biology from Fudan University, his work focuses on the mechanisms of RNA structures, molecular biology, and biophysics, with a strong emphasis on cryo-electron microscopy (Cryo-EM).

🧑‍🏫 Current Position

Postdoctoral Researcher
RNA Therapeutics Institute, UMass Medical School (2024–Present)

  • Research on RNA structures, particularly long non-coding RNAs (lncRNAs).
  • Focus on Cryo-EM techniques to elucidate RNA structural dynamics.

🎓 Education

Ph.D. in Structural Biology (2017–2023)
Fudan University, Shanghai, China

  • Research: Mechanisms and regulation of microRNA biogenesis and lncRNA structure.
    Master’s in Chemical Biology (2013–2016)
    Xiamen University, Xiamen, China
  • Research: Drug mechanisms targeting nuclear receptors.
    B.Sc. in Biotechnology (2008–2013)
    Jinggangshan University, Ji’an, China

đź’Ľ Professional Experience

Senior Research Assistant (2022–2023)
Cryo-EM Core Facility, Sichuan University, China

  • Managed operations for Titan Krios G3i, Talos Arctica G2, and JEOL1400 microscopes.
  • Applied Cryo-EM techniques for structural research.

Structural Biologist Researcher (2021–2022)
Runjia Pharmaceutical Technology Co., Ltd, Shanghai, China

  • Investigated ADAR inhibitors and their functions.

Research Assistant (2016–2017)
South University of Science and Technology of China, Shenzhen, China

  • Focused on microRNA biogenesis and its regulation.

đź“š Academic Publications

Dr. Ling has authored numerous peer-reviewed publications in top journals, including Nature, Nature Structural & Molecular Biology, and Cell Reports. Notable works include:

  1. Cryo-EM structure of a natural RNA nanocage (Nature, 2025)
  2. Circularly permuted group II introns and their mechanisms (Nature Structural & Molecular Biology, 2025)
  3. Human telomeric G-quadruplex DNA binding (BBA – Gene Regulatory Mechanisms, 2023)
  4. ADAR inhibitors and their function (prepint, 2022)

đź’ˇ Technical Skills

  • Cryo-EM: Expertise in cryo-electron microscopy for RNA and protein structural analysis.
  • RNA Structure Analysis: Proficient in the study of RNA folding and dynamics.
  • Molecular Biology: Strong background in RNA and DNA manipulation, including G-quadruplexes and microRNA biogenesis.
  • Computational Tools: Skilled in structural bioinformatics and molecular modeling.

👨‍🏫 Teaching Experience

Dr. Ling has contributed to academic training and mentoring at multiple institutions, particularly in structural biology and RNA research.

🔬 Research Interests On Data Science

  • Structural biology of RNA molecules, focusing on lncRNAs and their roles in gene regulation.
  • Application of Cryo-EM to explore the structural dynamics of RNA and protein complexes.
  • Investigating RNA-related therapeutic strategies, including the use of RNA nanocages and RNA-based drug delivery systems.

 📚 Top Notes Publications

Cryo-EM structure of a natural RNA nanocage
    • Authors: Xiaobin Ling*, Dmitrij Golovenko, Jianhua Gan, Jinbiao Ma*, Andrei A. Korostelev*, Wenwen Fang*
    • Journal: Nature
    • Year: 2025 (accepted)
Structures of a natural circularly permuted group II intron reveal mechanisms of branching and back-splicing
    • Authors: Xiaobin Ling*, Yuqi Yao*, Jinbiao Ma*
    • Journal: Nature Structural & Molecular Biology
    • Year: 2025
The mechanism of UP1 binding and unfolding of human telomeric G-quadruplex DNA
    • Authors: Xiaobin Ling#, Yuqi Yao#, Lei Ding, Jinbiao Ma*
    • Journal: Biochimica et Biophysica Acta (BBA) – Gene Regulatory Mechanisms
    • Year: 2023
DHX9 resolves G-quadruplex condensation to prevent DNA double-strand breaks
    • Authors: Juan Chen#, Xiaobin Ling#, Youshan Zhao#, Sheng Li, Manan Li, Hailian Zhao, Xianguang Yang, Chun-kang Chang, Jinbiao Ma*, Yuanchao Xue*
    • Journal: preprint
    • Year: 2022
Phytochrome B inhibits the activity of phytochrome-interacting factor 7 involving phase separation
    • Authors: Yu Xie, Wenbo Liu, Wenjing Liang, Xiaobin Ling, Jinbiao Ma, Chuanwei Yang, Lin Li*
    • Journal: Cell Reports
    • Year: 2023
Modular characterization of SARS-CoV-2 nucleocapsid protein domain functions in nucleocapsid-like assembly
    • Authors: Yan Wang#, Xiaobin Ling#, Jian Zou, Chong Zhang, Bingnan Luo, Yongbo Luo, Xinyu Jia, Guowen Jia, Minghua Zhang, Junchao Hu, Ting Liu, Yuanfeiyi Wang, Kefeng Lu, Dan Li, Jinbiao Ma*, Cong Liu*, Zhaoming Su*
    • Journal: Molecular Biomedicine
    • Year: 2023

 

Mohammad Reza Ahangari | Big Data Analytics | Best Researcher Award

Mr. Mohammad Reza Ahangari | Big Data Analytics | Best Researcher Award

Mr. Mohammad Reza Ahangari at ministry of education, Iran

👨‍🎓 Profile

🧠 Early Academic Pursuits

Dr. Mohammad Reza Ahangari’s journey into the realm of mathematics began with his undergraduate studies at Isfahan University of Technology, where he pursued a Bachelor of Applied Mathematics from 2003 to 2008. This foundational education provided him with a solid grounding in mathematical theories and applications. Following his undergraduate studies, Dr. Ahangari continued his academic journey at Azad University in Mashhad, Razavi Khorasan, earning a Master of Applied Mathematics between 2009 and 2012. His master’s program allowed him to delve deeper into complex mathematical concepts and research methodologies. His quest for knowledge did not end there; he embarked on a PhD in Applied Mathematics at Payam-e-Noor University, which he pursued from 2016 to 2024. His doctoral research focused on advanced mathematical models and optimization techniques, further cementing his expertise in the field.

đź’Ľ Professional Endeavors

Since September 2009, Dr. Ahangari has been a dedicated Mathematics Teacher with the Ministry of Education in Mashhad, Razavi Khorasan, Iran. Over the past 15 years, he has demonstrated a profound commitment to fostering a positive learning environment. His teaching approach is characterized by innovative lesson plans that cater to diverse learning styles, ensuring that all students have the opportunity to excel. Dr. Ahangari has consistently utilized various teaching methodologies and educational technologies to enhance student engagement and understanding of complex mathematical concepts. His ability to create engaging and effective learning experiences has made him a respected figure in the educational community.

🔬 Contributions and Research Focus

Dr. Ahangari’s research has made significant contributions to the field of applied mathematics. His work includes the development and application of advanced mathematical models and optimization techniques. Notably, he co-authored the paper “A Generalized Optimization-Based Generative Adversarial Network,” published in Expert Systems with Applications in 2024. This research explores innovative approaches to optimization in generative adversarial networks, demonstrating Dr. Ahangari’s expertise in integrating mathematics with cutting-edge technology. Additionally, his work on fuzzy-based structural similarity indices in meteorology, as detailed in his paper “Utilizing Generative Adversarial Networks Using a Category of Fuzzy-Based Structural Similarity Indices for Constructing Datasets in Meteorology,” showcases his ability to apply mathematical theories to real-world problems. His research contributions reflect a deep understanding of both theoretical and practical aspects of mathematics.

🏆 Accolades and Recognition

Dr. Ahangari’s dedication to mathematics education and research has been recognized through various accolades. He earned his Mathematics Teacher Certification in 2024, a testament to his expertise and commitment to the field. In 2023, he participated in professional development programs focused on advancing mathematics education, further highlighting his commitment to staying at the forefront of educational practices. His research contributions have also been acknowledged through publications in esteemed journals and presentations at significant seminars, such as the 6th Seminar on Control & Optimization in Birjand, Iran.

🌟 Impact and Influence

Dr. Ahangari’s impact on mathematics education extends beyond his teaching role. His innovative curriculum development and creation of interactive learning modules have significantly enhanced the educational experience for his students. His commitment to nurturing critical thinking and problem-solving skills in students has prepared them for future academic and professional challenges. By integrating advanced mathematical concepts with practical applications, Dr. Ahangari has influenced both his students and the broader educational community.

🌱 Legacy and Future Contributions

Looking forward, Dr. Ahangari aims to continue his contributions to both mathematics education and research. His ongoing projects include the development of a comprehensive math curriculum guide and the creation of interactive math learning modules. These initiatives reflect his dedication to enhancing educational resources and methodologies. As he continues to advance his research and educational practices, Dr. Ahangari is poised to leave a lasting legacy in the field of mathematics. His work not only advances mathematical knowledge but also inspires future generations of students and educators.

đź“– Publications

Manganese doped La0.8Ba0.2FeO3 perovskite oxide as an efficient electrode material for supercapacitor

    • Authors: Asadi, F., Ahangari, M., Mostafaei, J., Asghari, E., Niaei, A.
    • Journal: Journal of Alloys and Compounds
    • Year: 2024

A generalized optimization-based generative adversarial network

    • Authors: Farhadinia, B., Ahangari, M.R., Heydari, A., Datta, A.
    • Journal: Expert Systems with Applications
    • Year: 2024

Utilizing Generative Adversarial Networks Using a Category of Fuzzy-Based Structural Similarity Indices for Constructing Datasets in Meteorology

    • Authors: Farhadinia, B., Ahangari, M.R., Heydari, A.
    • Journal: Mathematics
    • Year: 2024

Effect of Pd doping on the structural properties and supercapacitor performance of La0.8Sr0.2Cu0.7Mn0.3O3 and La0.8Sr0.2Cu0.4Mn0.6O3 as electrode materials

    • Authors: Ahangari, M., Mostafaei, J., Zakerifar, H., Asghari, E., Niaei, A.
    • Journal: Electrochimica Acta
    • Year: 2023

Machine learning-based life cycle optimization for the carbon dioxide methanation process: Achieving environmental and productivity efficiency

    • Authors: Sayyah, A., Ahangari, M., Mostafaei, J., Nabavi, S.R., Niaei, A.
    • Journal: Journal of Cleaner Production
    • Year: 2023

Investigation of structural and electrochemical properties of SrFexCo1-xO3-δ perovskite oxides as a supercapacitor electrode material

    • Authors: Ahangari, M., Mostafaei, J., Sayyah, A., Delibas, N., Niaei, A.
    • Journal: Journal of Energy Storage
    • Year: 2023

Application of SrFeO3 perovskite as electrode material for supercapacitor and investigation of Co-doping effect on the B-site

    • Authors: Ahangari, M., Mahmoodi, E., DelibaĹź, N., Asghari, E., Niaei, A.
    • Journal: Turkish Journal of Chemistry
    • Year: 2022