Serena Nik-Zainal | Big Data Analytics | Best Researcher Award

Prof. Serena Nik-Zainal, Big Data Analytics, Best Researcher Award

Professor at University of Cambridge, United Kingdom

Professional Profile

Google Scholar Profile
Orcid Profile

🎓 Education 

  • University of Cambridge
    • B.A. (hons) – First, Physiology, 1998
    • M.B., B.Chir., Medicine/Surgery, 2000
  • Royal College of Physicians
    • M.R.C.P., Medicine, 2003
  • Wellcome Trust Sanger Institute
    • Ph.D., Cancer Genomics, 2012
  • Royal College of Physicians Specialist Register
    • Certification, Clinical Genetics, 2013

🌟 Personal Statement 

After earning a first-class degree in preclinical science and a medical degree from the University of Cambridge, sponsored by Petroliam Nasional Berhad Malaysia (PETRONAS) and as a Fellow of the Cambridge Commonwealth Trust, I specialized in Clinical Genetics. I have been an Honorary Consultant in Clinical Genetics at Cambridge University Hospitals NHS Foundation Trust since February 2013. My Ph.D. at the Wellcome Sanger Institute in 2012 focused on using next-generation sequencing (NGS) technology to explore cancer, leading to significant advancements in understanding tumor biology and mutational signatures. My current research integrates computational and experimental approaches to advance cancer genomics, developing machine-learning-based clinical algorithms and participating in large-scale projects like the UK 100,000 Genomes Project.

🏢 Positions and Honors 

Positions and Employment

  • Medical Student, University of Cambridge (1995-2000)
  • Pre-registration House Officer, East Anglian Deanery (2001-2002)
  • Senior House Officer, Medicine, East Anglian Deanery (2002-2004)
  • Specialist Registrar in Clinical Genetics, East Anglian Deanery (2004-2009)
  • Wellcome Clinical Research Training Fellow, Wellcome Sanger Institute (2009-2012)
  • Specialist Registrar in Clinical Genetics, East Anglian Deanery (2012-2013)
  • Wellcome Intermediate Clinical Research Training Fellow, Wellcome Sanger Institute (2013-2017)
  • Career Development Fellow, Wellcome Sanger Institute (2014-2017)
  • CRUK Advanced Clinician Scientist, University of Cambridge (2017-2021)
  • NIHR Research Professor of Genomic Medicine and Bioinformatics, University of Cambridge (2021-present)

Professional Memberships and Other Experience

  • Member, British Society of Genetic Medicine (2013-present)
  • EACR Ambassador (2015-present)
  • Member, Various Scientific Advisory Boards and Committees (2017-present)
  • Honorary NHS Consultant in Clinical Genetics, Cambridge University Hospital (2013-present)

Honors

  • Fellow of the Academy of Medical Sciences UK (2023)
  • Foulkes Foundation Medal UK (2021)
  • Sir Francis Crick Medal and Lecture from the Royal Society UK (2021)
  • Highly-Cited Researcher’s List Clarivate (2020)
  • EMBO Elected Fellow (2020)
  • Dr Josef Steiner Cancer Research Award (2019)
  • CRUK Pioneer Award (2016)
  • William Bate Hardy Prize (2014)
  • CRUK Future Leaders Prize (2014)
  • Wellcome-Beit Prize (2013)
  • AACR Scholar-in-training Award (2013)
  • EACR Susan G. Komen Prize (2012)
  • Robin Winter Prize (2012)

📚 Research Support 

Ongoing Research Support

  • NHSE Driver Project (Jan 2023-Mar 2024)
  • Breast Cancer Research Foundation (Oct 2022-ongoing)
  • CRUK/NIH Grand Challenge eDyNAmic (Jun 2022-May 2027)
  • UKRI DARE Sprint Exemplar (Jan 2022-Oct 2022)
  • NIHR Research Professorship (Dec 2021-Nov 2026)
  • Basser Gray Foundation Award (Dec 2020-Nov 2024)
  • Josef Steiner Award (Jun 2019-May 2023)

Completed Research Support

  • CRUK Early Detection Project Award (Jun 2019-May 2023)
  • CRUK Grand Challenge Award (May 2017-Apr 2024)
  • CRUK Advanced Clinician Scientist Award (Feb 2017-Oct 2022)
  • CRUK Pioneer Award (Oct 2016-Nov 2020)
  • Wellcome Trust Strategic Award (Sept 2013-July 2019)
  • Wellcome-Beit Prize (May 2013-May 2018)
  • Wellcome Intermediate Clinical Research Fellowship (Feb 2013-Jan 2017)

Beyond science, I have shared insights on women in STEM and my journey as a physician-scientist through essays in renowned journals.

đź“– Publication Top Noted:

Paper Title: The patterns and dynamics of genomic instability in metastatic pancreatic cancer
  • Authors: Peter J Campbell, Shinichi Yachida, Laura J Mudie, Philip J Stephens, Erin D Pleasance, Lucy A Stebbings, Laura A Morsberger, Calli Latimer, Stuart McLaren, Meng-Lay Lin, David J McBride, Ignacio Varela, Serena A Nik-Zainal, Catherine Leroy, Mingming Jia, Andrew Menzies, Adam P Butler, Jon W Teague, Constance A Griffin, John Burton, Harold Swerdlow, Michael A Quail, Michael R Stratton, Christine Iacobuzio-Donahue, P Andrew Futreal
  • Journal: Nature
  • Year:  2010
  • citations: 1560
Paper Title: Pan-cancer analysis of whole genomes
  • Authors: Dendy Adanta, Imam Syofii, Dewi Puspita Sari, Apri Wiyono
  • Journal: Nature
  • Year:  2020
  •  citations: 1736
Paper Title: Mutational signatures associated with tobacco smoking in human cancer
  • Authors:Ludmil B Alexandrov, Young Seok Ju, Kerstin Haase, Peter Van Loo, Iñigo Martincorena, Serena Nik-Zainal, Yasushi Totoki, Akihiro Fujimoto, Hidewaki Nakagawa, Tatsuhiro Shibata, Peter J Campbell, Paolo Vineis, David H Phillips, Michael R Stratton
  • Journal: Science
  • Year:  2016
  •  citations: 1034
Paper Title: Clock-like mutational processes in human somatic cells
  • Authors: Ludmil B Alexandrov, Philip H Jones, David C Wedge, Julian E Sale, Peter J Campbell, Serena Nik-Zainal, Michael R Stratton
  • Journal: Nature genetics
  • Year:  2015
  •  citations: 990
Paper Title: Heterogeneity of genomic evolution and mutational profiles in multiple myeloma
  • Authors: Niccolo Bolli, HervĂ© Avet-Loiseau, David C Wedge, Peter Van Loo, Ludmil B Alexandrov, Inigo Martincorena, Kevin J Dawson, Francesco Iorio, Serena Nik-Zainal, Graham R Bignell, Jonathan W Hinton, Yilong Li, Jose MC Tubio, Stuart McLaren, Sarah O’Meara, Adam P Butler, Jon W Teague, Laura Mudie, Elizabeth Anderson, Naim Rashid, Yu-Tzu Tai, Masood A Shammas, Adam S Sperling, Mariateresa Fulciniti, Paul G Richardson, Giovanni Parmigiani, Florence Magrangeas, Stephane Minvielle, Philippe Moreau, Michel Attal, Thierry Facon, P Andrew Futreal, Kenneth C Anderson, Peter J Campbell, Nikhil C Munshi
  • Journal: Nature communications
  • Year: 2014
  •  citations: 963

Nadia Dominici – Big Data Analytics – Best Researcher Award 

Dr. Nadia Dominici - Big Data Analytics - Best Researcher Award 

Vrije universitiet Amsterdam - Netherlands

Author Profile

Early Academic Pursuits

Dr. Nadia Dominici's academic journey reflects a profound commitment to understanding the intricacies of human movement sciences. Beginning with her undergraduate studies in Physics at the University of Rome "La Sapienza," her fascination with the mechanics of motion laid the foundation for her future endeavors. This background equipped her with a solid understanding of fundamental principles, which she later applied to her doctoral studies in Neuroscience at the University of Rome "Tor Vergata." Here, she delved into the neurophysiology of locomotor development in children, a pivotal area that would shape her career trajectory.

Professional Endeavors

Dominici's professional journey is marked by a series of strategic moves, each contributing to her expertise in human movement sciences. Her postdoctoral fellowships at esteemed institutions such as the Swiss Federal Institute of Technology Lausanne (EPFL) and the University of Zurich allowed her to collaborate with leading experts in the field, including Professors G. Courtine and F. Lacquaniti. These experiences broadened her perspective and honed her skills, preparing her for roles as a Senior Research Fellow and Assistant Professor at the Vrije Universiteit Amsterdam.

Contributions and Research Focus

Dominici's research focus is centered on unraveling the complexities of human locomotion, particularly in developmental stages. Her seminal work has contributed significantly to understanding the neural mechanisms underlying walking, from toddlers' first steps to the rehabilitation of individuals with neurological disorders. Her interdisciplinary approach, combining neuroscience, biomechanics, and physiology, has yielded groundbreaking insights into motor control and rehabilitation strategies.

Accolades and Recognition

Dominici's contributions to the field have been recognized through numerous awards and honors. Notably, she received the Suzanne Klein-Vogelbach Prize for the Research of Human Movement and the IgNobel Prize in Physics for her groundbreaking discoveries. These accolades underscore the significance of her research and its impact on both scientific and public discourse.

Impact and Influence

Dominici's work has had a profound impact on the field of human movement sciences, shaping our understanding of locomotor development and rehabilitation. Her innovative approaches have inspired researchers worldwide, fostering collaborations and driving advancements in neurorehabilitation. Through her mentorship and academic supervision, she continues to cultivate the next generation of scientists, ensuring a legacy of excellence and innovation.

Legacy and Future Contributions

As a Visiting Professor at New York University and an Associate Professor at Vrije Universiteit Amsterdam, Dominici remains at the forefront of research in human movement sciences. Her ongoing projects, including involvement in prestigious grants and supervisory roles, attest to her enduring commitment to advancing knowledge in the field. With a legacy built on curiosity, collaboration, and excellence, Dominici's future contributions are poised to further revolutionize our understanding of human locomotion and its implications for health and rehabilitation.

Notable Publication