Dr. Wuzheng Zhu | Qualitative Research | Research Excellence Award
College of Life Sciences | China
Dr. Wuzheng Zhu is a regenerative medicine researcher, specializing in mitochondrial biology, cellular repair, and stem‑cell therapies. He earned his Ph.D. in Biochemistry and Molecular Biology from Sichuan University’s Regenerative Medicine Research Center (West China Hospital). Currently based in the Laboratory of Animal Nutrition and Human Health, College of Life Sciences, Changsha, his work delves into the molecular mechanisms underlying mitochondrial homeostasis, particularly in the context of acute kidney injury and cardiovascular diseases. His lab combines biochemistry, molecular and cellular biology, drug screening, and mouse models to identify and manipulate mitochondrial regulation and repair pathways. Dr. Zhu has published extensively, with 5 documents, 306 citations, and an h‑index of 5, including influential studies on mesenchymal stem cell–mediated protection via mitophagy, mitochondrial dynamics in endothelial injury, lysosomal dysfunction in macrophage polarization, and suppression of ER stress in vascular cells. He has also investigated dietary intervention in piglet gut development. He is a recipient of the prestigious TTS‑CTRMS Scientific Congress Award in 2017. His research offers significant translational potential, aiming to harness mitochondrial modulation and stem-cell strategies for therapeutic intervention in metabolic and cardiovascular conditions.
Profile : Scopus
Featured Publications
Wei, J., Mao, R., Chen, Y., Si, K., Li, Y., Li, J., & Zhu, W. (2025). “MSCs ameliorates hyperglycemia-induced endothelial injury through modulation of mitochondrial dynamics” in Cell Death & Disease, 16(1), 832.
Mao, R.W., He, S.P., Lan, J.G., & Zhu, W.Z. (2022). “Honokiol ameliorates cisplatin‐induced acute kidney injury via inhibition of mitochondrial fission” in British Journal of Pharmacology.
Zhu, W., Yuan, Y., Liao, G., Li, L., Liu, J., Chen, Y., et al. (2018). “Mesenchymal stem cells ameliorate hyperglycemia-induced endothelial injury through modulation of mitophagy” in Cell Death & Disease, 9(8), 1–17.
Yuan, Y., Chen, Y., Peng, T., Li, L., Zhu, W., Liu, F., et al. (2019). “Mitochondrial ROS-induced lysosomal dysfunction impairs autophagic flux and contributes to M1 macrophage polarization in a diabetic condition” in Clinical Science, 133(15), 1759–1777.
Luo, R., Li, L., Liu, X., Yuan, Y., Zhu, W., Li, L., et al. (2020). “Mesenchymal stem cells alleviate palmitic acid-induced endothelial-to-mesenchymal transition by suppressing endoplasmic reticulum stress” in American Journal of Physiology-Endocrinology and Metabolism, 319(6), E961–E980.