Eric Holland | Big Data Analytics | Best Researcher Award

Posted on by ScienceFather

Prof Dr. Eric Holland, Big Data Analytics, Best Researcher Award

Prof Dr. Eric Holland at Fred Hutch Cancer Center, United States

Professional Profile

Scopus Profile
Google Scholar Profile

🌟 Summary

Eric Charles Holland is a distinguished researcher and academician specializing in neuro-oncology, currently serving as a Professor in the Human Biology Division at the Fred Hutchinson Cancer Research Center in Seattle, WA. With extensive experience spanning clinical practice and translational research, he has made significant contributions to understanding and treating brain tumors.

🎓 Education

Eric Charles Holland pursued an academic journey marked by excellence and dedication to biomedical sciences. He earned his Bachelor of Science degree in Chemistry from Miami University in Oxford, OH, from 1977 to 1981, setting a solid foundation in the fundamentals of chemical sciences. Continuing his academic pursuits, Holland completed his PhD in Biochemistry & Molecular Biology at the University of Chicago from 1981 to 1985, where he engaged deeply in the molecular mechanisms underlying biological processes. Following his PhD, he further expanded his expertise by obtaining an MD in Medicine from Stanford University between 1985 and 1990, thereby integrating clinical insights with his strong research background.

💼 Professional Experience

Eric Charles Holland is a distinguished figure in neuro-oncology with a robust professional trajectory spanning prestigious institutions and significant leadership roles. He currently holds the position of Professor in the Human Biology Division at the Fred Hutchinson Cancer Research Center in Seattle, WA, a role he has held since 2013. Previously, he served as the Director of the Nancy and Buster Alvord Brain Tumor Center at the University of Washington, Seattle, WA, from 2013 to 2019. Prior to that, he was an Attending Surgeon at Memorial Hospital for Cancer and Allied Diseases in New York, NY, from 2006 to 2013, where he also held an Associate Professorship at Cornell University from 2000 to 2006. His career is distinguished by his contributions to advancing neurosurgical techniques and his leadership in multidisciplinary research initiatives aimed at improving treatments for brain tumors.

🔬 Research Interests

Eric Charles Holland is renowned for his pioneering research in neuro-oncology, focusing particularly on gliomas, the most common type of brain tumor. His research spans from basic molecular biology to translational studies aimed at developing innovative therapies. Holland is deeply engaged in understanding the genetic and molecular mechanisms that drive glioma formation and progression, utilizing advanced techniques such as transgenic models to simulate human disease conditions. His work also delves into the complex interactions within the tumor microenvironment and their impact on treatment outcomes. Holland’s interdisciplinary approach integrates molecular biology, genetics, and clinical research, aiming to accelerate the translation of scientific discoveries into effective therapies for patients with brain tumors.

📖 Publication Top Noted

Paper Title: CSF-1R inhibition alters macrophage polarization and blocks glioma progression
    • Authors: Stephanie M Pyonteck, Leila Akkari, Alberto J Schuhmacher, Robert L Bowman, Lisa Sevenich, Daniela F Quail, Oakley C Olson, Marsha L Quick, Jason T Huse, Virginia Teijeiro, Manu Setty, Christina S Leslie, Yoko Oei, Alicia Pedraza, Jianan Zhang, Cameron W Brennan, James C Sutton, Eric C Holland, Dylan Daniel, Johanna A Joyce
    • Journal: Nature medicine
    • Year: 2013
Paper Title: A brain tumor molecular imaging strategy using a new triple-modality MRI-photoacoustic-Raman nanoparticle
    • Authors: Moritz F Kircher, Adam De La Zerda, Jesse V Jokerst, Cristina L Zavaleta, Paul J Kempen, Erik Mittra, Ken Pitter, Ruimin Huang, Carl Campos, Frezghi Habte, Robert Sinclair, Cameron W Brennan, Ingo K Mellinghoff, Eric C Holland, Sanjiv S Gambhir
    • Journal: Lecture Notes in Networks and Systems
    • Year: 2012
    •  citations: 1157
Paper Title: Genomic Analysis of Non-NF2 Meningiomas Reveals Mutations in TRAF7, KLF4, AKT1, and SMO
    • Authors: Victoria E Clark, E Zeynep Erson-Omay, Akdes Serin, Jun Yin, Justin Cotney, Koray Özduman, Timuçin Avşar, Jie Li, Phillip B Murray, Octavian Henegariu, Saliha Yilmaz, Jennifer Moliterno Günel, Geneive Carrión-Grant, Baran Yılmaz, Conor Grady, Bahattin Tanrıkulu, Mehmet Bakırcıoğlu, Hande Kaymakçalan, Ahmet Okay Caglayan, Leman Sencar, Emre Ceyhun, A Fatih Atik, Yaşar Bayri, Hanwen Bai, Luis E Kolb, Ryan M Hebert, S Bulent Omay, Ketu Mishra-Gorur, Murim Choi, John D Overton, Eric C Holland, Shrikant Mane, Matthew W State, Kaya Bilgüvar, Joachim M Baehring, Philip H Gutin, Joseph M Piepmeier, Alexander Vortmeyer, Cameron W Brennan, M Necmettin Pamir, Türker Kılıç, Richard P Lifton, James P Noonan, Katsuhito Yasuno, Murat Günel
    • Journal: Science
    • Year: 2013
    •  citations: 856
Paper Title: The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo
    • Authors:Jason T Huse, Cameron Brennan, Dolores Hambardzumyan, Boyoung Wee, John Pena, Sara H Rouhanifard, Cherin Sohn-Lee, Carlos Le Sage, Reuven Agami, Thomas Tuschl, Eric C Holland
    • Journal: Proceedings of the National Academy of Sciences
    • Year: 2009
    •  citations: 664
Paper Title: Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor response
  • Authors: Nicholas J Szerlip, Alicia Pedraza, Debyani Chakravarty, Mohammad Azim, Jeremy McGuire, Yuqiang Fang, Tatsuya Ozawa, Eric C Holland, Jason T Huse, Suresh Jhanwar, Margaret A Leversha, Tom Mikkelsen, Cameron W Brennan
  • Journal: Proceedings of the National Academy of Sciences
  • Year: 2012
  •  citations: 611

Serena Nik-Zainal | Big Data Analytics | Best Researcher Award

Posted on by ScienceFather

Prof. Serena Nik-Zainal, Big Data Analytics, Best Researcher Award

Professor at University of Cambridge, United Kingdom

Professional Profile

Google Scholar Profile
Orcid Profile

🎓 Education 

  • University of Cambridge
    • B.A. (hons) – First, Physiology, 1998
    • M.B., B.Chir., Medicine/Surgery, 2000
  • Royal College of Physicians
    • M.R.C.P., Medicine, 2003
  • Wellcome Trust Sanger Institute
    • Ph.D., Cancer Genomics, 2012
  • Royal College of Physicians Specialist Register
    • Certification, Clinical Genetics, 2013

🌟 Personal Statement 

After earning a first-class degree in preclinical science and a medical degree from the University of Cambridge, sponsored by Petroliam Nasional Berhad Malaysia (PETRONAS) and as a Fellow of the Cambridge Commonwealth Trust, I specialized in Clinical Genetics. I have been an Honorary Consultant in Clinical Genetics at Cambridge University Hospitals NHS Foundation Trust since February 2013. My Ph.D. at the Wellcome Sanger Institute in 2012 focused on using next-generation sequencing (NGS) technology to explore cancer, leading to significant advancements in understanding tumor biology and mutational signatures. My current research integrates computational and experimental approaches to advance cancer genomics, developing machine-learning-based clinical algorithms and participating in large-scale projects like the UK 100,000 Genomes Project.

🏢 Positions and Honors 

Positions and Employment

  • Medical Student, University of Cambridge (1995-2000)
  • Pre-registration House Officer, East Anglian Deanery (2001-2002)
  • Senior House Officer, Medicine, East Anglian Deanery (2002-2004)
  • Specialist Registrar in Clinical Genetics, East Anglian Deanery (2004-2009)
  • Wellcome Clinical Research Training Fellow, Wellcome Sanger Institute (2009-2012)
  • Specialist Registrar in Clinical Genetics, East Anglian Deanery (2012-2013)
  • Wellcome Intermediate Clinical Research Training Fellow, Wellcome Sanger Institute (2013-2017)
  • Career Development Fellow, Wellcome Sanger Institute (2014-2017)
  • CRUK Advanced Clinician Scientist, University of Cambridge (2017-2021)
  • NIHR Research Professor of Genomic Medicine and Bioinformatics, University of Cambridge (2021-present)

Professional Memberships and Other Experience

  • Member, British Society of Genetic Medicine (2013-present)
  • EACR Ambassador (2015-present)
  • Member, Various Scientific Advisory Boards and Committees (2017-present)
  • Honorary NHS Consultant in Clinical Genetics, Cambridge University Hospital (2013-present)

Honors

  • Fellow of the Academy of Medical Sciences UK (2023)
  • Foulkes Foundation Medal UK (2021)
  • Sir Francis Crick Medal and Lecture from the Royal Society UK (2021)
  • Highly-Cited Researcher’s List Clarivate (2020)
  • EMBO Elected Fellow (2020)
  • Dr Josef Steiner Cancer Research Award (2019)
  • CRUK Pioneer Award (2016)
  • William Bate Hardy Prize (2014)
  • CRUK Future Leaders Prize (2014)
  • Wellcome-Beit Prize (2013)
  • AACR Scholar-in-training Award (2013)
  • EACR Susan G. Komen Prize (2012)
  • Robin Winter Prize (2012)

📚 Research Support 

Ongoing Research Support

  • NHSE Driver Project (Jan 2023-Mar 2024)
  • Breast Cancer Research Foundation (Oct 2022-ongoing)
  • CRUK/NIH Grand Challenge eDyNAmic (Jun 2022-May 2027)
  • UKRI DARE Sprint Exemplar (Jan 2022-Oct 2022)
  • NIHR Research Professorship (Dec 2021-Nov 2026)
  • Basser Gray Foundation Award (Dec 2020-Nov 2024)
  • Josef Steiner Award (Jun 2019-May 2023)

Completed Research Support

  • CRUK Early Detection Project Award (Jun 2019-May 2023)
  • CRUK Grand Challenge Award (May 2017-Apr 2024)
  • CRUK Advanced Clinician Scientist Award (Feb 2017-Oct 2022)
  • CRUK Pioneer Award (Oct 2016-Nov 2020)
  • Wellcome Trust Strategic Award (Sept 2013-July 2019)
  • Wellcome-Beit Prize (May 2013-May 2018)
  • Wellcome Intermediate Clinical Research Fellowship (Feb 2013-Jan 2017)

Beyond science, I have shared insights on women in STEM and my journey as a physician-scientist through essays in renowned journals.

📖 Publication Top Noted:

Paper Title: The patterns and dynamics of genomic instability in metastatic pancreatic cancer
  • Authors: Peter J Campbell, Shinichi Yachida, Laura J Mudie, Philip J Stephens, Erin D Pleasance, Lucy A Stebbings, Laura A Morsberger, Calli Latimer, Stuart McLaren, Meng-Lay Lin, David J McBride, Ignacio Varela, Serena A Nik-Zainal, Catherine Leroy, Mingming Jia, Andrew Menzies, Adam P Butler, Jon W Teague, Constance A Griffin, John Burton, Harold Swerdlow, Michael A Quail, Michael R Stratton, Christine Iacobuzio-Donahue, P Andrew Futreal
  • Journal: Nature
  • Year:  2010
  • citations: 1560
Paper Title: Pan-cancer analysis of whole genomes
  • Authors: Dendy Adanta, Imam Syofii, Dewi Puspita Sari, Apri Wiyono
  • Journal: Nature
  • Year:  2020
  •  citations: 1736
Paper Title: Mutational signatures associated with tobacco smoking in human cancer
  • Authors:Ludmil B Alexandrov, Young Seok Ju, Kerstin Haase, Peter Van Loo, Iñigo Martincorena, Serena Nik-Zainal, Yasushi Totoki, Akihiro Fujimoto, Hidewaki Nakagawa, Tatsuhiro Shibata, Peter J Campbell, Paolo Vineis, David H Phillips, Michael R Stratton
  • Journal: Science
  • Year:  2016
  •  citations: 1034
Paper Title: Clock-like mutational processes in human somatic cells
  • Authors: Ludmil B Alexandrov, Philip H Jones, David C Wedge, Julian E Sale, Peter J Campbell, Serena Nik-Zainal, Michael R Stratton
  • Journal: Nature genetics
  • Year:  2015
  •  citations: 990
Paper Title: Heterogeneity of genomic evolution and mutational profiles in multiple myeloma
  • Authors: Niccolo Bolli, Hervé Avet-Loiseau, David C Wedge, Peter Van Loo, Ludmil B Alexandrov, Inigo Martincorena, Kevin J Dawson, Francesco Iorio, Serena Nik-Zainal, Graham R Bignell, Jonathan W Hinton, Yilong Li, Jose MC Tubio, Stuart McLaren, Sarah O’Meara, Adam P Butler, Jon W Teague, Laura Mudie, Elizabeth Anderson, Naim Rashid, Yu-Tzu Tai, Masood A Shammas, Adam S Sperling, Mariateresa Fulciniti, Paul G Richardson, Giovanni Parmigiani, Florence Magrangeas, Stephane Minvielle, Philippe Moreau, Michel Attal, Thierry Facon, P Andrew Futreal, Kenneth C Anderson, Peter J Campbell, Nikhil C Munshi
  • Journal: Nature communications
  • Year: 2014
  •  citations: 963

Cross-Border Analytics Mastery Accolade

Posted on by ScienceFather

Cross-Border Analytics Mastery Accolade

Cross-Border Analytics Mastery Accolade

Introduction: Step into the realm of global analytical excellence with the 'Cross-Border Analytics Mastery Accolade.' This prestigious award recognizes individuals who have demonstrated unparalleled expertise and innovation in the field of analytics, transcending borders and making a significant impact on the international stage.

Eligibility: The Cross-Border Analytics Mastery Accolade is open to analytics professionals, researchers, and innovators worldwide, celebrating those who have exhibited mastery in leveraging data insights across diverse geographical landscapes.

Age Limits: There are no age restrictions for this award, embracing individuals at any career stage who have showcased exceptional skills and achievements in the cross-border analytics domain.

Qualification: Applicants should present a distinguished record of excellence, demonstrating proficiency in applying analytics techniques to address challenges and opportunities that span international boundaries.

Publications and Requirements: While not mandatory, candidates may submit a portfolio highlighting significant analytics projects, publications, or innovations that showcase the depth and impact of their cross-border work.

Recurrences: The Cross-Border Analytics Mastery Accolade is presented periodically, recognizing ongoing contributions to the advancement of analytics practices across borders.

Evaluation Criteria: An esteemed panel of analytics experts will evaluate candidates based on the significance, originality, and broader impact of their cross-border analytics projects or initiatives.

Submission Guidelines: Nominees are encouraged to submit a comprehensive biography, an abstract summarizing key cross-border analytics achievements, and supporting files that provide evidence of the depth and impact of their work.

Recognition: Winners will receive global recognition for their outstanding contributions to cross-border analytics, with featured spotlights in leading analytics publications and international platforms.

Community Impact: Candidates should demonstrate a positive impact on the international analytics community or industries, embodying the spirit of cross-border collaboration and innovation.

Biography: Provide a detailed biography outlining the candidate's journey, achievements, and dedication to advancing cross-border analytics practices.

Abstract and Supporting Files: Include a compelling abstract summarizing the candidate's key achievements in cross-border analytics and attach supporting files that showcase the depth and impact of their work.

 

 

Cross-Border Analytics Pinnacle Award

Posted on by ScienceFather

Cross-Border Analytics Pinnacle Award

Cross-Border Analytics Pinnacle Award

introduction:

Welcome to the forefront of analytical excellence, where borders are no barrier to innovation. The 'Cross-Border Analytics Pinnacle Award' celebrates visionaries who transcend geographical boundaries, harnessing the power of analytics to drive global impact.

Eligibility: Open to analytics professionals worldwide, this award recognizes talent without age limits. Candidates must showcase an exemplary ability to leverage analytics across diverse borders.

Qualification: Applicants should demonstrate a proven track record of utilizing analytics in cross-border contexts, with a minimum of 5 years of professional experience in the analytics field.

Publications and Requirements: Candidates are encouraged to present a portfolio of publications showcasing their innovative use of analytics in cross-border scenarios. Original research papers, articles, or case studies are highly valued.

Evaluation Criteria: Judged on the innovation, impact, and global relevance of their analytical work, candidates will undergo a comprehensive evaluation by a panel of esteemed experts in cross-border analytics.

Submission Guidelines: Submissions must include a comprehensive biography, an abstract highlighting the candidate's cross-border analytics projects, and supporting files that exemplify the global impact of their work. Ensure all documents are submitted in a standard format.

Recognition: Winners will receive global recognition for their outstanding achievements, with featured spotlights in leading industry publications and international conferences.

Community Impact: Candidates should demonstrate a positive influence on the analytics community through cross-border collaborations, knowledge-sharing, or community-driven initiatives.

Biography: Provide a detailed biography outlining your journey, achievements, and impact on the cross-border analytics landscape.

Abstract and Supporting Files: Include a compelling abstract summarizing your key contributions in cross-border analytics and attach supporting files that showcase the depth and impact of your work